Natural product therapy for Bone disorders: Caffeine, one of the principal components of Coffee, inhibits osteoporosis and bone metastasis via up-regulation of its target gene. 13/October/2016, 5.55 pm

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A study from the Department of Pharmacology, The University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA has reported that “miR-34a blocks osteoporosis and bone metastasis by inhibiting osteoclastogenesis and Tgif2.”

This study was published in the June 25, 2014 Nature  [I.F >42] by Prof. Wan Y, Krzeszinski and others from  the Department of Pharmacology, The University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA.

On the foundation of this interesting finding, Dr L Boominathan, Director-cum-chief Scientist of GBMD, reports here that: Natural product therapy for Bone disorders: Caffeine,  one of the principal components of Coffee,  inhibits osteoporosis and bone metastasis via up-regulation of its target gene.


Idea Proposed/Formulated by: Dr L Boominathan PhD

Significance: 

Coffee, by up-regulating its target gene, it may suppress the expression of Tgif2. Together, this study suggests that pharmacological formulations encompassing “Coffee or its pharmacologically safer non-toxic analogs” can be used to inhibit osteoporosis and bone metastasis.

coffee

Coffeine, the major component of Coffee.

CitationBoominathan, Natural product therapy for Bone disorders: Caffeine,  one of the principal components of Coffee,  inhibits osteoporosis and bone metastasis via up-regulation of its target gene. 13/October/2016,  5.55 pm, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org

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Undisclosed information: How Caffeine suppresses the expression of Tgif2

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