Natural product therapy for brain repair and Life-span extension: Resveratrol, an activator of longevity promoting gene Sirtuin-1, increases VGF and BDNF expression, promotes Oligodendrocytes (OP) proliferation, triggers myelination on neurons, reverts neural damage, produces anti-depressant like effects, and prolongs lifespan via up-regulation of its target gene, 26/October/2016, 7.10 am

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What they say: Introduction:  

A recent study from the Department of Biochemistry & Molecular Pharmacology, Smilow Research Center, Howard Hughes Medical Institute, NYU School of Medicine, 522 First Avenue, New York, NY 10016, USA shows that “Voluntary Running Triggers VGF-Mediated Oligodendrogenesis to Prolong the Lifespan of Snf2h-Null Ataxic Mice.” This study was published in the 11 October 2016 issue of the Journal “Cell Reports” by Prof David J. Picketts, Dr. Matías Alvarez-Saavedra and others.

On the foundation of this interesting finding, Dr L Boominathan PhD, Director-cum-chief Scientist of GBMD, reports, for the first time, that: Natural product therapy for brain repair and Life-span  extension: Resveratrol, an activator of longevity promoting gene Sirtuin-1, increases VGF and BDNF expression, promotes Oligodendrocytes (OP) proliferation, triggers myelination on neurons, reverts neural damage, produces anti-depressant like effects, and prolongs lifespan via up-regulation of its target gene


What we say: Research Findings:

This study suggests a natural product-based therapy for brain repair and life-span extension.

Resveratrol, by increasing the expression of its target gene, it may increase the expression of VGF and BDNF. Thereby, it may: 1) promote OP proliferation, 2) trigger myelination on neurons, 3) revert neural damage, 4) confer protection against brain ischemia, 5) promote consolidation of hippocampal memory, 6) produce anti-depressant like effects, 7) enhance glucose-stimulated insulin secretion, 8) decrease stress hormones norepinephrine and epinephrine levels and blood pressure, and finally, as a consequence, 9) prolong lifespan

resveratrol

Figure1. Resveratrol, isolated from skin of red grapes, ground nut, dark chocolate, blue berries, among others, promotes brain repair and extends mammalian lifespan via up-regulation of VGF and BDNF

Thus, pharmacological formulations encompassing “Resveratrol or its analogs that have the ability to induce Sirtuin-1 expression or small molecules compounds that activate Sirtuin-1 expression” can be used to promote brain repair, treat neurodegenerative diseases (such as multiple sclerosis), and extend the lifespan of an individual.


Idea Proposed/Formulated (with factual evidence) by: Dr L Boominathan Ph.D.

Terms & Conditions apply http://genomediscovery.org/registration/terms-and-conditions/

Citation: Boominathan, Natural product therapy for brain repair and Life-span extension: Resveratrol, an activator of longevity promoting gene Sirtuin-1, increases VGF and BDNF expression, promotes Oligodendrocytes (OP) proliferation, triggers myelination on neurons, reverts neural damage, produces anti-depressant like effects, and prolongs lifespan via up-regulation of its target gene, 26/October/2016, 7.10 am, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org

Web: http://genomediscovery.org or newbioideas.com

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Undisclosed Information: How Resveratrol increases the expression of VGF and BDNF and promotes brain repair and mammalian life-span?

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