Natural product therapy for Myocardial Infarction: Avicularin, a bio-active flavonol isolated from Polygonum aviculare, Rhododendron aureum and Taxillus kaempferi, improves myocardial function after myocardial infarction via up regulation of PNUTS/PPP1R10 (Serine/threonine-protein phosphatase 1 regulatory subunit 10), 16/October/2016, 7.38 am

Natural product Immune enhancement therapy: Hyperoside, found in Drosera Rotundifolia and Prunella vulgaris (Common self-heal), increases SOX2 expression and promotes innate immunity against bacterial infection via down regulation of its target gene, 16/October/2016, 6.17 am
October 16, 2016
Natural product Antisepsis therapy: Neem leaf extract increases Sestrin2 expression, inhibits NLRP3 inflammasome activation, and pro-inflammatory cytokines secretion, induces mitophagy in macrophages, and clears damaged mitochondria via autophagic machinery, and protects the host from sepsis via up- regulation of its target gene, 17/October/2016, 10. 19 pm
October 17, 2016
Show all

A recent study from the Institute for Cardiovascular Regeneration, Centre of Molecular Medicine, Frankfurt, Germany shows that “MicroRNA-34a regulates cardiac ageing and function.” This study was published in the 7 March  2013 issue of Nature  by Prof Dimmler, Boon, and others.

On the foundation of this interesting finding, Dr L Boominathan PhD, Director-cum-chief Scientist of GBMD, reports that: Natural product therapy for Myocardial Infarction: Avicularin, a bio-active flavonol isolated from Polygonum aviculare, Rhododendron aureum and Taxillus kaempferi,   improves myocardial function after myocardial infarction via  up regulation of PNUTS/PPP1R10 (Serine/threonine-protein phosphatase 1 regulatory subunit 10)


Significance:

Given that: (1)  cardiovascular disease is the leading cause of death worldwide; (2) in India, in 2004, 14.6 lakhs deaths (14% of total deaths) were due to ischemic heart disease; and (3) the global economic cost spent in the treatment of cardiovascular disease in 2011 was little more than 10 billion US dollars, there is an urgent need to find: (i)  a way to induce regeneration of adult cardiomyocytes that were lost in Myocardial patients; (ii) a cheaper alternative to the existing expensive drugs; and (iii) a side-effect-free drug.

This study suggests a natural product-based cardiac regeneration therapy. Avicularin, by increasing the expression of its target gene, it may increase the expression of PNUTS/PPP1R10. Thereby, it may: (1) inhibit DNA damage responses, (2) inhibit telomere shortening; and (3) promote cardiomyocyte survival/regeneration.

Avicularin promotes myocardial survival and prevents myocardial infarction via up-regualtion of PNUTS//PPP1R10

Avicularin, found in Taxillus kaempferi,  promotes myocardial survival and prevents myocardial infarction via up-regulation of PNUTS//PPP1R10

Thus, by treating myocardial patients with avicularin, one may prevent ageing-associated (or, stress-associated) decline in cardiac function. Together, this study suggests that pharmacological

Avicularin

Avicularin

Rhododendron aureum

Avicularin is also found in Rhododendron aureum

formulations encompassing “Avicularin or its analogues  may be used to improve cardiac

Polygonum aviculare

Avicularin is also found in Polygonum aviculare

function after myocardial infarction.  

 


Idea Proposed/Formulated byDr L Boominathan Ph.D.

Web:http://genomediscovery.org or http://newbioideas.com

To citeBoominathan, Natural product therapy for Myocardial Infarction: Avicularin, a bio-active flavonol isolated from Polygonum aviculare, Rhododendron aureum and Taxillus kaempferi,   improves myocardial function after myocardial infarction via  up regulation of PNUTS/PPP1R10 (Serine/threonine-protein phosphatase 1 regulatory subunit 10)16/October/2016, 7.38 am,  Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org

Courtesy: When you cite drop us a line at info@genomediscovery.org


Undisclosed information: How Avicularin increases the expression of PNUTS/PPP1R10

Terms & Conditions apply http://genomediscovery.org/registration/terms-and-conditions/

Amount: $300#

Results guaranteed if not refunded

# Research cooperation

Comments are closed.