A recent study from Rutgers Cancer Institute of New Jersey, Rutgers University, The State University of New Jersey, New Brunswick, New Jersey, USA shows that “Cullin3–KLHL25 ubiquitin ligase targets ACLY for degradation to inhibit lipid synthesis and tumor progression.” This study was published in the 1 September 2016 issue of Genes Development by Prof Feng Z, Zhang C, and others.
On the foundation of this interesting finding, Dr L Boominathan PhD, Director-cum-chief Scientist of GBMD, reports that: Natural product therapy targeting aberrant Lipid synthesis in Human cancers: Guggulsterone (a farnesoid X receptor antagonist) suppresses the expression of the principal enzyme in lipid synthesis, ACLY, inhibits aberrant lipid production, and tumor progression via up regulation of its target gene
Given that cancer causes the highest economic loss compared to all the known causes of human death worldwide, there is an urgent need to find: (i) a cheaper alternative to the existing expensive drugs; (ii) a side-effect-free natural product-based drug that targets abnormal bio-fuel requirements of cancer cells; (iii) a way to effectively treat cancers that are resistant to anti-cancer drugs; and (iv) a way to effectively treat and eradicate metastatic progression of cancer.
This study suggests, for the first time, that Guggulsterone, by increasing the expression of its target gene, it may suppress the expression of ATP-Citrate lyase (ACLY). Remarkably, a number of human tumors over express ACLY, suggesting that inhibition of its activity may inhibit aberrant lipid synthesis in cancer cells, and thereby increase the efficacy of anticancer therapy.
Thus, pharmacological formulations encompassing “Guggulsterone or its analogues” may be used to treat human cancers that specifically overexpress ACLY.
Idea Proposed/Formulated by: Dr L Boominathan Ph.D.
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To cite: Boominathan, Natural product therapy targeting aberrant Lipid synthesis in Human cancers: Guggulsterone (a farnesoid X receptor antagonist) suppresses the expression of the principal enzyme in lipid synthesis, ACLY, inhibits aberrant lipid production, and tumor progression via up regulation of its target gene, 10/October/2016, 11.35 pm, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org
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Undisclosed information: How Guggulsterone inhibits the expression of ACLY?