Natural product therapy for aged patients with Myocardial Infarction: Berberine, an isoquinoline alkaloid isolated from Phellodendron amurense, and Tinospora cordifolia, induces autophagy in cardiomyocytes, inhibits cardiomyocyte hypertrophy, improves myocardial function in Post myocardial-infarction patients via up-regulation of PPAR-α, PNUTS/PPP1R10 and Sirutin1, 21/October/2016, 1.31 pm
A recent study from the Institute of Molecular and Translational Therapeutic Strategies, Hannover Medical School, Hannover, Germany; Excellence Cluster REBIRTH, Hannover Medical School, Hannover, Germany; and National Heart and Lung Institute, Imperial College, London, United Kingdom shows that “Preclinical Development of a MicroRNA-Based Therapy for Elderly Patients With Myocardial Infarction.” This study was published in […]
Natural product anti-inflammatory therapy for upper respiratory tract inflammatory diseases: Hyperoside, found in Drosera Rotundifolia and Prunella vulgaris (Common self-heal), increases the expression of negative regulator of inflammation MyD88(s), inhibits pro-inflammatory mediators in lungs, and alleviates the common respiratory pathogen nontypeable Haemophilus influenzae (NTHi)-exacerbated asthma & chronic obstructive pulmonary disease via up-regulation of its target gene, 21/October/2015, 7.55 am
A study from the Center for Inflammation, Immunity &Infection, Institute for Biomedical Sciences, Georgia State University, Atlanta, GA, 30303, USA shows that: “Resveratrol suppresses NTHi-induced inflammation via up-regulation of the negative regulator MyD88 short.” This study was published in the 28 September 2016 issue of the journal “Scientific reports” by Prof. Li JD, Andrews CS […]
Molecular therapy for Myocardial dysfunction: Metformin, one of the widely used drugs in the treatment of TIIDM, increases CDK inhibitor p27 expression, inhibits mTOR pathway, promotes autophagy in myocardial cells and prevents myocardial dysfunction via down-regulation of its target gene, 21/October/2016, 6.15 am
Dr L Boominathan PhD, Director-cum-chief Scientist of GBMD, reports here that: Molecular therapy for Myocardial dysfunction: Metformin, one of the widely used drugs in the treatment of TIIDM, increases CDK inhibitor p27 expression, inhibits mTOR pathway, promotes autophagy in myocardial cells and prevents myocardial dysfunction via down-regulation of its target gene Significance: Given that: (1) cardiovascular disease […]
Natural product therapy for tuberculosis: Avacado (Persea Americana) fruit extract increases the expression of MKP-1, inhibits TLR2 signalling, secretion of Chemokine CXCL5, and recruitment of polymorphonuclear leukocytes (PMNs), decreases destructive pulmonary inflammation, promotes M. tuberculosis clearance and inhibits pulmonary tuberculosis via up-regulation of its target gene, 20/October/2016, 10.51 pm
A study from the Max Plank Institute for Infection Biology, Berlin, Germany shows that “CXCL5-secreting pulmonary epithelial cells drive destructive neutrophilic inflammation in tuberculosis.” This study was published in the 10 February 2014 issue of the“Journal of Clinical Investigations” [One of the best research journals in clinical medicine with an impact factor of 12.575] by […]
Natural product Antisepsis therapy: Epigallocatechin gallate, one of the components in green tea, increases Sestrin2 expression, inhibits NLRP3 inflammasome activation, and pro-inflammatory cytokines secretion, induces mitophagy in macrophages, and clears damaged mitochondria via autophagic machinery, and protects the host from sepsis via up- regulation of its target gene, 20/October/2016, 10.05 pm
A recent study from the Yonsei University College of Medicine, Seoul, Korea shows that Sestrin2 suppresses Sepsis by inducing mitophagy and inhibiting NLRP3 activation. This study was published in the 2 August 2016 issue of the Journal “Autophagy” [the number one journal in autophagy with an impact factor of 10+] by Drs. Yoon JH, Kim […]
Natural product therapy targeting aberrant Lipid synthesis in Human cancers: Withaferin A, isolated from Withania somnifera (Ashwagandha), suppresses the expression of the principal enzyme in lipid synthesis, ACLY, inhibits aberrant lipid production, and tumor progression via up regulation of its target gene, 20/October/2016, 8.54 pm
A recent study from Rutgers Cancer Institute of New Jersey, Rutgers University, The State University of New Jersey, New Brunswick, New Jersey, USA shows that “Cullin3–KLHL25 ubiquitin ligase targets ACLY for degradation to inhibit lipid synthesis and tumor progression.” This study was published in the 1 September 2016 issue of Genes Development by Prof Feng Z, Zhang C, and others. On the foundation of this […]
