What they say: Introduction:
A recent study from the Department of Genetics, Paul F. Glenn Laboratories for the Biological Mechanisms of Aging Harvard Medical School, Boston,USA; and Department of Pharmacology, School of Medicine, The University of New South Wales, Australia shows that Sirtuin-2 induces the checkpoint kinase BubR1 to increase lifespan. This study was published in the 1 July 2014 issue of the journal “EMBO” by Prof Sinclair, North BJ, and others.
On the foundation of this interesting finding, Dr L Boominathan PhD, Director-cum-chief Scientist of GBMD, reports that: Vitamin-based Lifespan extension therapy: α-Tocopherol (Vitamin-E) increases life span via up-regulation of its target gene BubR1.
What we say: Research Findings:
This study suggests aVitamin-based life extension therapy.
α-Tocopherol (Vitamin-E), by increasing the expression of its target gene, it may increase the expression of BuBR1. Thereby, it may: (1) delay diseases of aging; (2) slow down aging; and (3) prolong median life span. Thus, pharmacological formulations encompassing “α-Tocopherol (Vitamin-E) or its analogues“ may be used to extend the lifespan of an individual. Alternatively, any combination of “BubR1 inducers” (for instance, Curcumin and Green tea extract combo may superinduce BubR1) can be used to extend the lifespan of an individual.
Idea Proposed/Formulated by: Dr L Boominathan Ph.D.
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Citation: Boominathan, Vitamin-based Lifespan extension therapy: α-Tocopherol (Vitamin-E) increases life span via up-regulation of its target gene BubR1, 30/October/2016, 1.08 pm, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org
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Undisclosed information: How α-Tocopherol (Vitamin-E) increases the expression of BubR1 and extends mammalian life-span
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