Monthly Archives: November 2016

Cardiac rejuvenation therapy: SNAI1 , a positive regulator of epithelial-mesenchymal transitions, suppresses tumor suppressor INK4a/p16 expression, and inhibits dilated cardiomyopathy and heart failure via up regulation of its target gene, 30/November/2015, 11.14 pm

Introduction: What they say A recent study from the Stem Cell Aging Group, Centro Nacional de Investigaciones Cardiovasculares, E-28029 Madrid, Spain shows that “Bmi1 limits dilated cardiomyopathy and heart failure by inhibiting cardiac senescence.” This study was published in the online journal 9 March  2015 issue of Nature Communications by Prof Gonzalez, Gonzalez-Valdes and others. What … Continue reading

Posted in Ideas | Comments Off on Cardiac rejuvenation therapy: SNAI1 , a positive regulator of epithelial-mesenchymal transitions, suppresses tumor suppressor INK4a/p16 expression, and inhibits dilated cardiomyopathy and heart failure via up regulation of its target gene, 30/November/2015, 11.14 pm

Natural product-based therapy for Cardiomyopathy: Areca nut extract or Arecoline induces the expression of Trbp/miR-208, restores the balance between slow- and fast-twitch myofiber proteins and alleviates Cardiomyopathy via up regulation of its target gene, 30/November/2016, 6.59 pm

Introduction: What they say: A study from the Department of Cardiology, Boston Children’s Hospital, Harvard Medical School, Boston, Massachusetts, USA; and Harvard Stem Cell Institute, Harvard University, Cambridge, Massachusetts, USA shows that “Trbp regulates heart function through microRNA-mediated Sox6 repression.“This study was published … Continue reading

Posted in Ideas | Comments Off on Natural product-based therapy for Cardiomyopathy: Areca nut extract or Arecoline induces the expression of Trbp/miR-208, restores the balance between slow- and fast-twitch myofiber proteins and alleviates Cardiomyopathy via up regulation of its target gene, 30/November/2016, 6.59 pm

Natural product-based cardioprotective therapy: Fisetin, isolated from Strawberry, blueberries, mangoes, apples, persimmon, kiwi, onions, grapes and cucumber among others, increases Spermidine levels, augments autophagy, mitophagy and mitochondrial respiration, lowers systemic blood pressure, and protects it from cardiac diseases via down regulation of its target gene , 30/November/2015, 3.09 pm

Introduction: What they say A study from the Institute of Molecular Biosciences, University of Graz, Humboldtstraße 50, A-8010 Graz shows that “Cardioprotection and lifespan extension by the natural polyamine spermidine.” This research paper was published in the 14 November 2016 … Continue reading

Posted in Ideas | Comments Off on Natural product-based cardioprotective therapy: Fisetin, isolated from Strawberry, blueberries, mangoes, apples, persimmon, kiwi, onions, grapes and cucumber among others, increases Spermidine levels, augments autophagy, mitophagy and mitochondrial respiration, lowers systemic blood pressure, and protects it from cardiac diseases via down regulation of its target gene , 30/November/2015, 3.09 pm

Natural product-derived therapy for Myocardial Infarction: Piceatannol, found in the seeds of passion fruit (Passiflora edulis), inhibits DNA damage responses, and telomere shortening, and promotes cardiomyocyte survival after myocardial infarction via up-regulation of PNUTS, 30/November/2016, 9.29 am

What they say:  A recent study from the Institute for Cardiovascular Regeneration, Centre of Molecular Medicine, Frankfurt, Germany shows that “MicroRNA-34a regulates cardiac ageing and function.” This study was published in the 7 March  2013 issue of Nature  by Prof Dimmler, Boon, and others. What we say:  On the foundation of this interesting finding, Dr L Boominathan … Continue reading

Posted in Ideas | Comments Off on Natural product-derived therapy for Myocardial Infarction: Piceatannol, found in the seeds of passion fruit (Passiflora edulis), inhibits DNA damage responses, and telomere shortening, and promotes cardiomyocyte survival after myocardial infarction via up-regulation of PNUTS, 30/November/2016, 9.29 am

Natural product-based therapy for Regenerating the lost cardiomyocytes in Myocardial patients: 2,4,5-trihydroxybenzaldehyde (TDB), found in Geum japonicum and Polygonum cuspidatum (PC), also known as Japanese knotweed, increases the expression of ERBB2/Her2 and promotes dedifferentiation of cardiomyocytes via down regulation of its target gene, 30/November/2016, 5.54 am

Introduction: What they say A recent study from the Department of Biological Regulation, Weizmann Institute of Science, Rehovot 76100, Israel shows that “ERBB2 triggers mammalian heart regeneration by promoting cardiomyocyte dedifferentiation and proliferation.” This study was published in the 6 April  2015 issue of the journal “Nature … Continue reading

Posted in Ideas | Comments Off on Natural product-based therapy for Regenerating the lost cardiomyocytes in Myocardial patients: 2,4,5-trihydroxybenzaldehyde (TDB), found in Geum japonicum and Polygonum cuspidatum (PC), also known as Japanese knotweed, increases the expression of ERBB2/Her2 and promotes dedifferentiation of cardiomyocytes via down regulation of its target gene, 30/November/2016, 5.54 am

Natural product-derived therapy for Intestinal cancer: American Ginseng increases the expression of DNA Sensor AIM2 and inhibits expansion of tumor-initiating intestinal stem cell population via up regulation of its target gene, 29/November/2016, 11.47 pm

What they say: Introduction: A recent study from the Department of Immunology, Saint Jude Children’s Research Hospital, Memphis, TN 38105, USA shows that:  “Critical Role for the DNA Sensor AIM2 in Stem Cell Proliferation and Cancer”. This study was published in … Continue reading

Posted in Ideas | Comments Off on Natural product-derived therapy for Intestinal cancer: American Ginseng increases the expression of DNA Sensor AIM2 and inhibits expansion of tumor-initiating intestinal stem cell population via up regulation of its target gene, 29/November/2016, 11.47 pm

MiRNA-based PD-1 pathway blockade for Human cancer therapy: MiR-3646 inhibits the expression of co-inhibitory receptor PD-1 on Antigen- Specific T-cells, increases the production of cytokines by tumor-infiltrating lymphocytes (TIL), and draining lymph nodes and augments anti-tumor activity via down-regulation of its target gene, 29/November/2016, 10.04 pm

Introduction:What they say:   A recent study from Division of Infectious Diseases, School of Medicine, Johns Hopkins University, Baltimore, MD 21218, United States shows that “TGF-β1-Mediated Smad3 Enhances PD-1 Expression on Antigen-Specific T Cells in Cancer.” This study was published … Continue reading

Posted in Ideas | Comments Off on MiRNA-based PD-1 pathway blockade for Human cancer therapy: MiR-3646 inhibits the expression of co-inhibitory receptor PD-1 on Antigen- Specific T-cells, increases the production of cytokines by tumor-infiltrating lymphocytes (TIL), and draining lymph nodes and augments anti-tumor activity via down-regulation of its target gene, 29/November/2016, 10.04 pm

Natural product-derived therapy for tuberculosis: Ganoderma lucidum, a medicinal/herbal mushroom, increases the expression of MKP-1, inhibits TLR2 signalling, secretion of Chemokine CXCL5, and recruitment of polymorphonuclear leukocytes (PMNs), decreases destructive pulmonary inflammation, promotes M. tuberculosis clearance and inhibits pulmonary tuberculosis via up-regulation of its target gene, 29/November/2016, 8.39 pm

Introduction: What they say:  A study from the Max Plank Institute for Infection Biology, Berlin, Germany shows that “CXCL5-secreting pulmonary epithelial cells drive destructive neutrophilic inflammation in tuberculosis.” This study was published in the 10 February 2014 issue of the“Journal of … Continue reading

Posted in Ideas | Comments Off on Natural product-derived therapy for tuberculosis: Ganoderma lucidum, a medicinal/herbal mushroom, increases the expression of MKP-1, inhibits TLR2 signalling, secretion of Chemokine CXCL5, and recruitment of polymorphonuclear leukocytes (PMNs), decreases destructive pulmonary inflammation, promotes M. tuberculosis clearance and inhibits pulmonary tuberculosis via up-regulation of its target gene, 29/November/2016, 8.39 pm

Natural product-derived anti-ageing therapy: 2,4,5-trihydroxybenzaldehyde (TDB), found in Geum japonicum and Polygonum cuspidatum (PC), also known as Japanese knotweed, increases NMN levels, decreases age-associated weight gain, augments energy metabolism, improves physical activity and insulin sensitivity, promotes healthy lipid profile, and improves eye function via down regulation of its target gene, 29/November/2015, 10.10 am

Introduction: What they say A study from Gladstone Institute of Neurological Disease and Department of Neurology, University of California, San Francisco, San Francisco, CA 94158, USA and Department of Developmental Biology, Washington University School of Medicine, Saint Louis, MO 63110, … Continue reading

Posted in Ideas | Comments Off on Natural product-derived anti-ageing therapy: 2,4,5-trihydroxybenzaldehyde (TDB), found in Geum japonicum and Polygonum cuspidatum (PC), also known as Japanese knotweed, increases NMN levels, decreases age-associated weight gain, augments energy metabolism, improves physical activity and insulin sensitivity, promotes healthy lipid profile, and improves eye function via down regulation of its target gene, 29/November/2015, 10.10 am

Molecular therapy for Myocardial Infarction: PPARδ improves myocardial function after myocardial infarction via up-regulation of PNUTS, 29/November/2016, 6.00 am

Introduction: What they say:  A recent study from the Institute for Cardiovascular Regeneration, Centre of Molecular Medicine, Frankfurt, Germany shows that “MicroRNA-34a regulates cardiac ageing and function.” This study was published in the 7 March  2013 issue of Nature  by Prof Dimmler, Boon, and others. What we say:  On the foundation of this interesting finding, Dr L … Continue reading

Posted in Ideas | Comments Off on Molecular therapy for Myocardial Infarction: PPARδ improves myocardial function after myocardial infarction via up-regulation of PNUTS, 29/November/2016, 6.00 am

Natural product Life-span extension therapy: N(1), N(11)-Diethylnorspermine, a spermine analog, may increase life span by suppressing mTOR pathway, 28/November/2016, 11.13 pm

What is known:  It has been shown earlier that decreasing the expression/activity of mTOR increases overall mammalian lifespan, suggesting that mTOR inhibitors may function as “longevity promoters” From research findings to therapeutic opportunity:  This study suggests that N(1), N(11)-Diethylnorspermine, by suppressing the expression … Continue reading

Posted in Ideas | Comments Off on Natural product Life-span extension therapy: N(1), N(11)-Diethylnorspermine, a spermine analog, may increase life span by suppressing mTOR pathway, 28/November/2016, 11.13 pm

Natural product anti-inflammatory therapy for upper respiratory tract inflammatory diseases: Eriocitrin, isolated from lemons, increases the expression of negative regulator of inflammation MyD88(s), inhibits pro-inflammatory mediators in lungs, and alleviates the common respiratory pathogen nontypeable Haemophilus influenzae (NTHi)-exacerbated asthma & chronic obstructive pulmonary disease via up-regulation of its target gene, 28/November/2015, 10.45 pm

Introduction: What they say:  A study from the Center for Inflammation, Immunity & Infection, Institute for Biomedical Sciences, Georgia State University, Atlanta, GA, 30303, USA shows that: “Resveratrol suppresses NTHi-induced inflammation via up-regulation of the negative regulator MyD88 short.” This … Continue reading

Posted in Ideas | Comments Off on Natural product anti-inflammatory therapy for upper respiratory tract inflammatory diseases: Eriocitrin, isolated from lemons, increases the expression of negative regulator of inflammation MyD88(s), inhibits pro-inflammatory mediators in lungs, and alleviates the common respiratory pathogen nontypeable Haemophilus influenzae (NTHi)-exacerbated asthma & chronic obstructive pulmonary disease via up-regulation of its target gene, 28/November/2015, 10.45 pm

Molecular therapy for triple-negative breast tumors: BMP4 increases the levels of cell cycle inhibitor, p27, inhibits pro-survival pathways mediated by c-Myc, and inhibits the progression of triple-negative breast cancer via up-regulation of its target gene, 28/November/2015, 7.04 pm

Introduction: What they say A study from the Department of Cell and Tissue Biology, University of California, San Francisco (UCSF), San Francisco, California, USA shows that “PIM1 kinase inhibition as a targeted therapy against triple-negative breast tumors with elevated MYC … Continue reading

Posted in Ideas | Comments Off on Molecular therapy for triple-negative breast tumors: BMP4 increases the levels of cell cycle inhibitor, p27, inhibits pro-survival pathways mediated by c-Myc, and inhibits the progression of triple-negative breast cancer via up-regulation of its target gene, 28/November/2015, 7.04 pm

Anti-metastasis therapy: Anticancer drug Campothecin (CPT) decreases PDPN expression, invasion, migration and metastasis of tumor cells via up regulation of its target gene, 28/November/2016, 6.55 pm

Research findings to Therapeutic opportunity:  The study presented here suggests that Anticancer drug Campothecin (CPT), by increasing the expression of its target genes, it may decrease the expression of oncoprotein PDPN. Thereby, it may inhibit proliferation, migration, invasion,  and metastasis of … Continue reading

Posted in Ideas | Comments Off on Anti-metastasis therapy: Anticancer drug Campothecin (CPT) decreases PDPN expression, invasion, migration and metastasis of tumor cells via up regulation of its target gene, 28/November/2016, 6.55 pm

Anticancer therapy: MiRNA-9600 increases the expression of pro-apoptotic protein Fas ligand (FasL) and inhibits proliferation, chemoresistance and apoptosis of cancer cells via down regulation of its target gene, 28/November/2016, 6.46 pm

Research findings to Therapeutic opportunity:  The study presented here suggests that MiRNA-9600, by decreasing the expression of its target genes, it may increase the expression of pro-apoptotic protein Fas Ligand (FasL). Thereby, it may inhibit proliferation, chemoresistance and apoptosis of cancer cells. Thus, pharmacological … Continue reading

Posted in Ideas | Comments Off on Anticancer therapy: MiRNA-9600 increases the expression of pro-apoptotic protein Fas ligand (FasL) and inhibits proliferation, chemoresistance and apoptosis of cancer cells via down regulation of its target gene, 28/November/2016, 6.46 pm

Molecular therapy for Myocardial Infarction: MiR-301 improves myocardial function after myocardial infarction via up-regulation of PNUTS, 28/November/2016, 12.22 pm

Introduction: What they say:  A recent study from the Institute for Cardiovascular Regeneration, Centre of Molecular Medicine, Frankfurt, Germany shows that “MicroRNA-34a regulates cardiac ageing and function.” This study was published in the 7 March  2013 issue of Nature  by Prof Dimmler, Boon, and others. What we say:  On the foundation of this interesting finding, Dr L … Continue reading

Posted in Ideas | Comments Off on Molecular therapy for Myocardial Infarction: MiR-301 improves myocardial function after myocardial infarction via up-regulation of PNUTS, 28/November/2016, 12.22 pm

Therapeutic insights into “awakening the sleeping angel” in mutant p53-expressing human tumors: MiR-103 increases the expression of tumor suppressor p53 homologue TAp73 and induces regression of p53-mutated human tumors via down regulation of its target gene, 28/November/2016, 6.24 am

From Significance of the study to Public health relevance: Given that: (1) Cancer suppressor p53 is mutated in more than 50% of human cancers of different tissue origin; (2) p53 pathway is altered in about 80% of tumors.; (3) our … Continue reading

Posted in Ideas | Comments Off on Therapeutic insights into “awakening the sleeping angel” in mutant p53-expressing human tumors: MiR-103 increases the expression of tumor suppressor p53 homologue TAp73 and induces regression of p53-mutated human tumors via down regulation of its target gene, 28/November/2016, 6.24 am

Molecular therapy for Myocardial Infarction: Long ncRNA NEAT improves myocardial function after myocardial infarction via up-regulation of PNUTS, 27/November/2016, 10.14 pm

Introduction: What they say:  A recent study from the Institute for Cardiovascular Regeneration, Centre of Molecular Medicine, Frankfurt, Germany shows that “MicroRNA-34a regulates cardiac ageing and function.” This study was published in the 7 March  2013 issue of Nature  by Prof Dimmler, Boon, and others. What we say:  On the foundation of this interesting finding, Dr L … Continue reading

Posted in Ideas | Comments Off on Molecular therapy for Myocardial Infarction: Long ncRNA NEAT improves myocardial function after myocardial infarction via up-regulation of PNUTS, 27/November/2016, 10.14 pm

Antimetastasis therapy: MiRNA-9600 increases the expression of tumor suppressor long ncRNA GAS5 and inhibits migration, invasion and metastasis of cancer cells via down regulation of its target gene, 27/November/2016, 8.29 pm

Research findings to Therapeutic opportunity:  The study presented here suggests that MiRNA-9600, by decreasing the expression of its target genes, it may increase the expression of tumor suppressor long ncRNA GAS5. Thereby, it may inhibit migration, invasion, and metastasis. Thus, pharmacological formulations encompassing … Continue reading

Posted in Ideas | Comments Off on Antimetastasis therapy: MiRNA-9600 increases the expression of tumor suppressor long ncRNA GAS5 and inhibits migration, invasion and metastasis of cancer cells via down regulation of its target gene, 27/November/2016, 8.29 pm

Anti-metastasis therapy: Tumor suppressor ING1b/p33 decreases PDPN expression, invasion, migration and metastasis of tumor cells via up regulation of its target gene, 27/November/2015, 8.16 pm

Research findings to Therapeutic opportunity:  The study presented here suggests that tumor suppressor ING1b/p33, by increasing the expression of its target genes, it may decrease the expression of oncoprotein PDPN. Thereby, it may inhibit proliferation, migration, invasion,  and metastasis of cancer … Continue reading

Posted in Ideas | Comments Off on Anti-metastasis therapy: Tumor suppressor ING1b/p33 decreases PDPN expression, invasion, migration and metastasis of tumor cells via up regulation of its target gene, 27/November/2015, 8.16 pm