Natural product Lifespan extension therapy: N-methylpyridinium (NMP), one of the constituents of Coffee, increases life span via up-regulation of its target gene BubR1, 1/November/2016, 10.33 pm
What they say: Introduction: A recent study from the Department of Genetics, Paul F. Glenn Laboratories for the Biological Mechanisms of Aging Harvard Medical School, Boston,USA; and Department of Pharmacology, School of Medicine, The University of New South Wales, Australia shows that Sirtuin-2 induces the checkpoint kinase BubR1 to increase lifespan. This study was published in the 1 July 2014 issue of the journal “EMBO” by Prof […]
Natural product therapy for triple-negative breast tumors: Curcumin analog EF24 increases the levels of cell cycle inhibitor, p27, inhibits pro-survival pathways mediated by c-Myc, and inhibits the progression of triple-negative breast cancer via up-regulation of its target gene, 1/November/2015, 7.07 pm
Introduction: What they say A study from the Department of Cell and Tissue Biology, University of California, San Francisco (UCSF), San Francisco, California, USA shows that “PIM1 kinase inhibition as a targeted therapy against triple-negative breast tumors with elevated MYC expression” Another study, carried out in parallel, from the Breast Cancer Now Research Unit, Division […]
Natural product therapy for Oropharyngeal candidiasis (OPC): Resveratrol, an activator of longevity-promoting gene Sirtuin-1, increases IL-17R and antimicrobial peptide ß-defensin 3 (BD3, Defb3) expression and promotes resistance against infections caused by Candida albicans via up-regulation of its target gene, 1/November/2015, 1.02 pm
Introduction: What they say A study from the Division of Rheumatology and Clinical Immunology, University of Pittsburgh, Pittsburgh, PA 15261, USA; and Department of Mucosal and Salivary Biology, King’s College London, London SE1 1UL, UK shows that “IL-17 Receptor Signaling in Oral Epithelial Cells Is Critical for Protection against Oropharyngeal Candidiasis.” This research paper was […]
Natural product Anti-telomerase cancer therapy: Amla (Emblica officinalis) extract suppresses the expression of Tripeptidyl Peptidase 1 (TPP1) and inhibits cancer progression via down-regulation of its target gene, 1/November/2016, 10.56 am
What they say: Introduction: The 1989 Nobel prize winner in Chemistry, Prof. Thomas R. Cech from the BioFrontiers Institute, USA has published a research paper in the 13 December 2012 Nature (492(7428):285-9; and I.F: >42) stating that “The TEL patch of telomere protein TPP1 mediates telomerase recruitment and processivity.” This study provides mechanistic insights into how TPP1 regulates telomerase function. What we say: In connection with the finding presented above, Dr Boominathan, Founder Director-cum-chief scientist of GBMD, reports […]
Natural product-based PD-1 pathway blockade for Human cancer therapy: Avacado (Persea Americana var. Hass ) extract inhibits the expression of co-inhibitory receptor PD-1 on Antigen- Specific T-cells, increases the production of cytokines by tumor-infiltrating lymphocytes (TIL), and draining lymph nodes and augments anti-tumor activity via down-regulation of its target gene, 1/November/2016, 10.45 am
Introduction:What they say: A recent study from Division of Infectious Diseases, School of Medicine, Johns Hopkins University, Baltimore, MD 21218, United States shows that “TGF-β1-Mediated Smad3 Enhances PD-1 Expression on Antigen-Specific T Cells in Cancer.” This study was published in the 28 September 2016 issue of Cancer Discovery (one of the best journals in Cancer […]
