What they say:
A study from the Department of Cancer Biology, Dana-Farber Cancer Institute; Department of Cell Biology, Harvard Medical School, USA; and others shows that “Cyclin D1–Cdk4 controls glucose metabolism independently of cell cycle progression.” This study was published in the June 26, 2014 Nature [One of the best journals in Science with an I.F of 38.138] by Prof. Puigserver, Lee and others.
What we say:
On the foundation of this interesting finding, Dr L Boominathan, Director-cum-chief Scientist of GBMD, reports here that: Natural product therapy for NIDDM: Oleic acid,found in Safflower, olive, canola, Hazelnut, sunflower oils, Avacados, almond and sunflower among others, inhibits gluconeogenesis and hyperglycemia via up regulation of Cyclin D1.
Public health relevance:
Given that: (1) more than 387 million people worldwide are affected by Diabetes mellitus (DM); (2) the life-long painful injection/drug treatment is required to treat DM; (3) the global economic cost spent for diabetes treatment in 2014 was little more than 600 billion US dollars, there is an urgent need to find: (i) a way to induce regeneration of adult β-cells that were lost in DM; (ii) a way to increase insulin sensitivity in obese individuals; (iii) a cheaper alternative to the existing expensive weight-loss drugs; (iv) a side-effect-free natural product-based drug; and (v) a way to cure, not just treat, diabetes.
From Research findings to Therapeutic opportunity:
I have shown earlier that Oleic acid: (1) protects against stress-induced heart failure via up regulation of SNX13; (2) increases life span via up regulation of BubR1 and Sirtuin-1; (3) decreases brain infarct size/damage, edema formation, neutrophil infiltration and promotes neuronal survival via down regulation of TIM-3; (4) improves myocardial function after myocardial infarction via up regulation of PNUTS/PPP1R10; (5) increases insulin-secreting cell mass and function via down regulation of PTEN and PDCD4; (6) increases insulin sensitivity and promotes glucose homeostasis via upregulation of XBP1s; (7) prevents heart failure via down regulation of Type 5-cardiac adenylyl cyclase; (8) promotes the generation of cardiomyocyte-like cells from differentiated cells by decreasing the expression of Snai; (9) inhibits pulmonary hypertension; and (10) functions as an anti-cancer agent etc.
This study suggests, for the first time, a natural product based therapy for TIIDM. Oleic acid, by up regulating its target gene, it may increase the expression of cell cycle protein Cyclin-D1. Thereby, it may inhibit gluconeogenesis and hyperglycemia.
Thus, pharmacological formulations encompassing “Oleic acid or its analogues” may be used to treat TIIDM.
Together, this study suggests that pharmacological formulations encompassing “Oleic acid or its analogues or Oleic acid plus any of the known anti-hyperglycemic compounds“ may be used in the treatment of NIDDM.
Details of the research findings:
Idea Proposed/Formulated (with experimental evidence) by:
Dr L Boominathan Ph.D.
Terms & Conditions apply http://genomediscovery.org/registration/terms-and-conditions/
Undisclosed information: How Oleic acid increases the expression of Cyclin D1?
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Citation: Boominathan, L., Natural product therapy for NIDDM: Oleic acid, found in Safflower, olive, canola, Hazelnut, sunflower oils, Avacados, almond and sunflower among others, inhibits gluconeogenesis and hyperglycemia via up regulation of Cyclin D1., Genome-2-Bio-Medicine Discovery center (GBMD), 22/November/2016, 10.46 pm., http://genomediscovery.org
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