What they say:
A recent study from the Institute for Cardiovascular Regeneration, Centre of Molecular Medicine, Frankfurt, Germany shows that “MicroRNA-34a regulates cardiac ageing and function.” This study was published in the 7 March 2013 issue of Nature by Prof Dimmler, Boon, and others.
What we say:
On the foundation of this interesting finding, Dr L Boominathan PhD, Director-cum-chief Scientist of GBMD, reports that: Natural product-derived therapy for Myocardial Infarction: Piceatannol, found in the seeds of passion fruit (Passiflora edulis), inhibits DNA damage responses, and telomere shortening, and promotes cardiomyocyte survival after myocardial infarction via up-regulation of PNUTS
From Significance of the study to Public Health relevance:
Given that: (1) cardiovascular disease is the leading cause of death worldwide; (2) the raise of death rate, due to cardiovascular disease, has increased from 123 lakhs in 1990 to 173 lakhs in 2013; (3) 85% of people over 80 years are susceptible to cardiovascular diseases;(4) in India, in 2004, 14.6 lakhs deaths (14% of total deaths) were due to ischemic heart disease; (3) the death due to cardiovascular disease is higher in low-to-middle income countries compared to developed countries; (4) the global economic cost spent in the treatment of cardiovascular disease in 2011 was little more than 10 billion US dollars; (5) an alarming number of people, such as 230 lakhs people, will die from cardiovascular diseases each year by 2030, there is an urgent need to find: (i) a way to induce regeneration of cardiomyocytes that were lost in Myocardial patients; (ii) a cheaper alternative to the existing expensive drugs; and (iv) a side-effect-free Natural product-based drug.
What is known?
I have published earlier that Piceatannol improves myocardial function after myocardial infarction via up-regulation of PNUTS (Natural product-based therapy for Myocardial Infarction: Piceatannol, a natural compound found in passion fruit (Passiflora edulis), improves myocardial function after myocardial infarction via up regulation of PNUTS/PPP1R10 (Serine/threonine-protein phosphatase 1 regulatory subunit 10), 2/November/2014, 23.10).
From Research Findings to Therapeutic Opportunity:
This study provides mechanistic insight into how Piceatannol increases the expression of PNUTS.
Piceatannol, found in Passiflora edulis (figure 1), by increasing the expression of its target genes (figure 3), it may increase the expression of PNUTS. Thereby, it may: (1) inhibit DNA damage responses, (2) inhibit telomere shortening; and (3) promote cardiomyocyte survival/regeneration.
Thus, by treating myocardial patients with Piceatannol (figure 2), one may prevent ageing-associated (or, stress-associated) decline in cardiac function. Together, this study suggests that pharmacological formulationsencompassing “Piceatannol or its analogues or Piceatannol plus any of the known drugs that improve myocardial function” may be used to improve cardiac function after myocardial infarction.
Details of the research findings:
Idea Proposed/Formulated (with experimental evidence) by:
Dr L Boominathan Ph.D.
Terms & Conditions apply http://genomediscovery.org/registration/terms-and-conditions/
Undisclosed information: How Puerarin increases the expression of PNUTS
# Research cooperation
Citation: Boominathan, L., Natural product-derived therapy for Myocardial Infarction: Piceatannol, found in the seeds of passion fruit (Passiflora edulis), inhibits DNA damage responses, and telomere shortening, and promotes cardiomyocyte survival after myocardial infarction via up-regulation of PNUTS, 30/November/2016, 9.29 am, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org
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