Research findings to Therapeutic opportunity:
The study presented here suggests that tumor suppressor ING1b/p33, by increasing the expression of its target genes, it may decrease the expression of oncoprotein PDPN.
Thereby, it may inhibit proliferation, migration, invasion, and metastasis of cancer cells. Thus, pharmacological formulations encompassing “ING1b/p33 activators” may be used to inhibit the progression of invasive tumors.
Details of the research findings:
Idea Proposed/Formulated (with experimental evidence) by:
Dr L Boominathan Ph.D.
Undisclosed information: How tumor suppressor ING1b/p33 decreases the expression of metastasis suppressor PDPN
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Citation: Boominathan, L., Anti-metastasis therapy: Tumor suppressor ING1b/p33 decreases PDPN expression, invasion, migration and metastasis of tumor cells via up regulation of its target gene, 27/November/2015, 8.16 pm, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org
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