Natural product-based Cardiac rejuvenation therapy: Methyl 3,5-dicaffeoyl quinate (MDQ), a flavonoid glucoside found in Castor-aralia (kalopanax-pictus), Salicornia herbacea L., Aster oharai and Solidago virga-aurea var. gigantean, suppresses tumor suppressor INK4a/p16 expression, and inhibits dilated cardiomyopathy and heart failure via up regulation of its target gene, 18/November/2015, 7.04 am

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Introduction: What they say

A recent study from the Stem Cell Aging Group, Centro Nacional de Investigaciones Cardiovasculares, E-28029 Madrid, Spain shows that “Bmi1 limits dilated cardiomyopathy and heart failure by inhibiting cardiac senescence.” This study was published in the online journal 9 March  2015 issue of Nature Communications by Prof GonzalezGonzalez-Valdes and others.


What we say: 

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On the foundation of this interesting finding, Dr L Boominathan PhD, Director-cum-chief Scientist of GBMD, reports that: Natural product-based Cardiac rejuvenation therapy: Methyl 3,5-dicaffeoyl quinate (MDQ), a flavonoid glucoside found in Castor-aralia (kalopanax-pictus), Salicornia herbacea L., Aster oharai and Solidago virga-aurea var. gigantean,  suppresses tumor suppressor p16(INK4a) expression, and inhibits dilated cardiomyopathy and heart failure via up regulation of its target gene


Significance:

Given that: (1)  cardiovascular disease is the leading cause of death worldwide; (2) Dilated cardiomyopathy is the leading cause of Heart failure; (3) in India, in 2004, 14.6 lakhs deaths (14% of total deaths) were due to ischemic heart diseaseand (4) the global economic cost spent in the treatment of cardiovascular disease in 2011 was little more than 10 billion US dollars, there is an urgent need to find: (i)  a way to induce regeneration of adult cardiomyocytes that were lost in Myocardial patients; (ii) a cheaper alternative to the existing expensive drugs; and (iii) a side-effect-free natural product-based drug.


From research findings to therapeutic opportunity: 

This study suggests, for the first time, a Natural productbased cardiac rejuvenation therapy.

This study suggests, for the first time, that Methyl 3,5-dicaffeoyl quinate (MDQ), by increasing the expression of its target gene, it may suppress the expression of tumor suppressor and the ageing marker INK4a/p16Thereby, it may: (1) inhibit cardiac senescence; (2) increase of regenerative potential in aged tissues; and (3) improve ventricular dimensions and contractility. By treating myocardial patients with Methyl 3,5-dicaffeoyl quinate (MDQ), one may prevent Dilated cardiomyopathy and ageing-associated (or, stress-associated) decline in cardiac function. 

Castor-aralia (kalopanax-pictus)

Methyl 3,5-dicaffeoyl quinate (MDQ), found in Castor-aralia (kalopanax-pictus) among others, as indicated below, inhibits dilated cardiomyopathy and heart failure via down regulation of ageing marker INKa/p16

Salicornia herbacea L

Salicornia herbacea L

Thus, pharmacological formulations encompassing Methyl 3,5-dicaffeoyl quinate (MDQ) or its analogues may be used to inhibit dilated cardiomyopathy and heart failure.

Image result for Methyl 3,5-dicaffeoyl quinate

Methyl 3,5-dicaffeoyl quinate (MDQ)


Details of the research findings

Idea Proposed/Formulated byDr L Boominathan Ph.D.

Terms & Conditions apply http://genomediscovery.org/registration/terms-and-conditions/

* Research cooperation

Undisclosed information: How Methyl 3,5-dicaffeoyl quinate (MDQ) suppresses the expression of tumor suppressor p16(INK4a).


References:

Web: http://genomediscovery.org or newbioideas.com

CitationBoominathan, L., Cardiac rejuvenation therapy: Methyl 3,5-dicaffeoyl quinate (MDQ), a flavonoid glucoside found in Castor-aralia (kalopanax-pictus), Salicornia herbacea L., Aster oharai and Solidago virga-aurea var. gigantean,  suppresses tumor suppressor INK4a/p16 expression, and inhibits dilated cardiomyopathy and heart failure via up regulation of its target gene, 18/November/2015,  7.04 am,  Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org

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