Interleukin-based Lifespan extension therapy: IL-23 (Interleukin-23) increases life span via up-regulation of its target gene BubR1, 8/November/2016, 12.32 pm

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 What they say: Introduction: 

A recent study from the Department of Genetics, Paul F. Glenn Laboratories for the Biological Mechanisms of Aging Harvard Medical School, Boston,USA; and Department of Pharmacology, School of Medicine, The University of New South Wales, Australia shows that Sirtuin-2 induces the checkpoint kinase BubR1 to increase lifespan. This study was published in the 1 July  2014 issue of the journal  “EMBO” by Prof Sinclair, North BJ, and others.

What we say: 

On the foundation of this interesting finding, Dr L Boominathan PhD, Director-cum-chief Scientist of GBMD, reports that:  Interleukin-based Lifespan extension therapy: IL-23 (Interleukin-23) increases life span via up-regulation of its target gene BubR1

From Research Findings to Therapeutic Opportunity: 

This study suggests an interleukin-based life extension therapy. IL-23, by increasing the expression of its target gene, it may increase the expression of BuBR1. Thereby, it may: (1) delay diseases of aging; (2) slow down aging; and (3) prolong median life span. Thus, pharmacological formulations encompassing“IL-23  or its activators may be used to extend the lifespan of an individual. 

Idea Proposed/Formulated byDr L Boominathan Ph.D.

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CitationBoominathan, L., Interleukin-based Lifespan extension therapy: IL-23 (Interleukin-23) increases life span via up-regulation of its target gene BubR1, 8/November/2016, 12.32 pm,  Genome-2-Bio-Medicine Discovery center (GBMD),

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Undisclosed information: How IL-23  increases the expression of BubR1 and extends mammalian life-span

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