Introduction: What they say:
A recent study from the Institute for Cardiovascular Regeneration, Centre of Molecular Medicine, Frankfurt, Germany shows that “MicroRNA-34a regulates cardiac ageing and function.” This study was published in the 7 March 2013 issue of Nature by Prof Dimmler, Boon, and others.
What we say:
On the foundation of this interesting finding, Dr L Boominathan PhD, Director-cum-chief Scientist of GBMD, reports that: Molecular therapy for Myocardial Infarction: Long ncRNA NEAT improves myocardial function after myocardial infarction via up-regulation of PNUTS
Given that: (1) cardiovascular disease is the leading cause of death worldwide; (2) in India, in 2004, 14.6 lakhs deaths (14% of total deaths) were due to ischemic heart disease; and (3) the global economic cost spent in the treatment of cardiovascular disease in 2011 was little more than 10 billion US dollars, there is an urgent need to find: (i) a way to induce regeneration of adult cardiomyocytes that were lost in Myocardial patients; (ii) a cheaper alternative to the existing expensive drugs; and (iii) a side-effect-free drug.
From Research Findings to Therapeutic Opportunity:
This study suggests an RNA-based cardiac regeneration therapy. Long ncRNA NEAT, by decreasing the expression of its target gene, it may increase the expression of PNUTS. Thereby, it may: (1) inhibit DNA damage responses, (2) inhibit telomere shortening; and (3) promote cardiomyocyte survival/regeneration.
Thus, by treating cardiac patients with Long ncRNA NEAT activators, one may prevent ageing-associated (or, stress-associated) decline in cardiac function. Together, this study suggests that “Long ncRNA NEAT or its activators” can be used to improve myocardial function and prevent myocardial infarction.
Details of the Research findings:
Idea Proposed/Formulated (with experimental evidence) by:
Dr L Boominathan Ph.D.
Undisclosed Mechanistic insights: How does Long ncRNA NEAT increase the expression of PNUTS?
Terms & Conditions apply http://genomediscovery.org/registration/terms-and-conditions/
# Research cooperation
Citation: Boominathan, L., Molecular therapy for Myocardial Infarction: Long ncRNA NEAT improves myocardial function after myocardial infarction via up-regulation of PNUTS, 27/November/2016, 10.13 pm, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org
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