What they say:
A recent study from the Institute for Cardiovascular Regeneration, Centre of Molecular Medicine, Frankfurt, Germany shows that “MicroRNA-34a regulates cardiac ageing and function.” This study was published in the 7 March 2013 issue of Nature by Prof Dimmler, Boon, and others.
What we say:
On the foundation of this interesting finding, Dr L Boominathan PhD, Director-cum-chief Scientist of GBMD, reports that: Molecular therapy for Myocardial Infarction: miR-380-5p improves myocardial function after myocardial infarction via up-regulation of PNUTS
Given that: (1) cardiovascular disease is the leading cause of death worldwide; (2) in India, in 2004, 14.6 lakhs deaths (14% of total deaths) were due to ischemic heart disease; and (3) the global economic cost spent in the treatment of cardiovascular disease in 2011 was little more than 10 billion US dollars, there is an urgent need to find: (i) a way to induce regeneration of adult cardiomyocytes that were lost in Myocardial patients; (ii) a cheaper alternative to the existing expensive drugs; and (iii) a side-effect-free drug.
From Research Findings to Therapeutic Opportunity:
This study suggests small molecule-based cardiac regeneration therapy. JAK3, by decreasing the expression of its target gene, it may increase the expression of PNUTS. Thereby, it may: (1) inhibit DNA damage responses, (2) inhibit telomere shortening; and (3) promote cardiomyocyte survival/regeneration.
Thus, by treating cardiac patients with miR-380-5p or its activators, one may prevent ageing-associated (or, stress-associated) decline in cardiac function. Together, this study suggests that miR-380-5p activators can be used to improve myocardial function and prevent myocardial infarction.
Idea Proposed/Formulated (with experimental evidence) by:
Dr L Boominathan Ph.D.
To cite: Boominathan, L., Molecular therapy for Myocardial Infarction: miR-380-5p improves myocardial function after myocardial infarction via up-regulation of PNUTS, 11/November/2016, 11.22 pm, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org
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# Research cooperation
Undisclosed information (Mechanistic insights): How does miR-380-5p increase the expression of PNUTS?
Terms & Conditions apply http://genomediscovery.org/registration/terms-and-conditions/
Attention: Kindly understand that this idea was posted earlier by us, but then we lost it on our website because somebody had hacked our website in the second week of Oct, 2015. We are in the process of recovering our ideas posted earlier, especially from May, 2015 to October, 2015. So, this idea is re-posted for the sake of the researchers.