Molecular therapy for Regenerating the lost pancreatic β-cells in Diabetic patients: Long ncRNA CCAT1 promotes an insulin-sensitized state via up-regulation of reprogramming protein Lin28, 27/November/2016, 6.39 am

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What we say

On the foundation of this interesting finding, Dr L Boominathan PhD, Director-cum-chief Scientist of GBMD, reports that: Molecular therapy for Regenerating the lost pancreatic β-cells in Diabetic patients: Long ncRNA CCAT1 promotes an insulin-sensitized state via up-regulation of reprogramming protein Lin28

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Significance

Given that (1)  more than 387 million people worldwide are affected by Diabetes mellitus (DM); (2) the life-long painful injection/drug treatment is required to treat DM; and (3) the global economic cost spent for diabetes treatment in 2014 was little more than 600 billion US dollars, there is an urgent need to find a way to induce regeneration of adult β-cells that were lost in DM.


From Research findings to Therapeutic opportunity:

This study suggests, for the first time, that Long ncRNA CCAT1, by decreasing the level of its target gene, it may increase the expression of RNA-binding protein Lin-28. Thereby, it may (1) increase the expression of IGF1R, INSR,and IRS2; (2) enhance tissue repair; (3) promote youthful regenerative capacity; and (4) promote insulin sensitivity. Thus, pharmacological formulations encompassing “Long ncRNA CCAT1 activators” may be used to treat DM.


Details of the research findings: 

Idea Proposed/Formulated (with experimental evidence) by:

Dr L Boominathan Ph.D.

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Undisclosed information: How Long ncRNA CCAT1 increases the expression of Lin28

Amount: $100

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References:

CitationBoominathan L, Molecular therapy for Regenerating the lost pancreatic β-cells in Diabetic patients: Long ncRNA CCAT1 promotes an insulin-sensitized state via up-regulation of reprogramming protein Lin28, 27/November/2016, 6.39 am,  Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org

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