Natural product Anti-telomerase cancer therapy: Amla (Emblica officinalis) extract suppresses the expression of Tripeptidyl Peptidase 1 (TPP1) and inhibits cancer progression via down-regulation of its target gene, 1/November/2016, 10.56 am

Natural product-based PD-1 pathway blockade for Human cancer therapy: Avacado (Persea Americana var. Hass ) extract inhibits the expression of co-inhibitory receptor PD-1 on Antigen- Specific T-cells, increases the production of cytokines by tumor-infiltrating lymphocytes (TIL), and draining lymph nodes and augments anti-tumor activity via down-regulation of its target gene, 1/November/2016, 10.45 am
November 1, 2016
Natural product therapy for Oropharyngeal candidiasis (OPC): Resveratrol, an activator of longevity-promoting gene Sirtuin-1, increases IL-17R and antimicrobial peptide ß-defensin 3 (BD3, Defb3) expression and promotes resistance against infections caused by Candida albicans via up-regulation of its target gene, 1/November/2015, 1.02 pm
November 1, 2016
Show all

What they say: Introduction: 

The 1989 Nobel prize winner in Chemistry, Prof. Thomas R. Cech from the BioFrontiers Institute, USA has published a research paper in the 13 December 2012 Nature (492(7428):285-9; and I.F: >42) stating that “The TEL patch of telomere protein TPP1 mediates telomerase recruitment and processivity.”  This study provides mechanistic insights into how TPP1 regulates telomerase function.


What we say: 

In connection with the finding presented above, Dr Boominathan, Founder Director-cum-chief scientist of GBMD, reports that: Natural product Anti-telomerase cancer therapy: Amla (Emblica officinalis) extract suppresses the expression of Tripeptidyl Peptidase 1 (TPP1) and inhibits cancer progression via down-regulation of its target gene


Significance:

Given that cancer causes the highest economic loss compared to all the known causes of death worldwide, there is an urgent need to find: (i) a cheaper alternative to the existing expensive drugs; (ii) a side-effect-free natural product-based drug; (iii) a way to effectively treat cancers that are resistant to anti-cancer drugs; and (iv) a way to effectively treat and eradicate metastatic progression of cancer.


Figure 1 Emblica Officianalis (amla or generally known as Goose berry) extract Figure 1 Moringa Olifera tree. Moringa Olifera extract inhibits human cancer cell proliferation via down-regulation of Tripeptidyl Peptidase 1 (TPP1) and telomerase

Figure 1 Emblica Officianalis (Amla or generally known as Goose berry) extract Figure 1 Moringa Olifera tree. Moringa Olifera extract inhibits human cancer cell proliferation via down-regulation of Tripeptidyl Peptidase 1 (TPP1) and telomerase

From Research Findings to Therapeutic opportunity:

Idea Proposed/Formulated by:

Dr L Boominathan Ph.D.

Amla extract (Emblica officinalis), by increasing the expression of its target gene, it may suppress the expression of Tripeptidyl Peptidase 1 (TPP1). Remarkably, over 90% human tumors over express telomerase, suggesting that inhibition of its activity may increase the efficacy of anticancer therapy.  Thus, this study suggests that pharmacological formulations encompassing “Amla extract (Emblica officinalis) or an active compound isolated from it may be used to treat human cancers.


CitationBoominathan, L., Natural product Anti-telomerase cancer therapy: Amla (Emblica officinalis) extract suppresses the expression of Tripeptidyl Peptidase 1 (TPP1) and inhibits cancer progression via down-regulation of its target gene, 1/November/2016, 10.56 am,  Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org

Terms & Conditions apply http://genomediscovery.org/registration/terms-and-conditions/

Courtesy: When you cite drop us a line at info@genomediscovery.org

Web: http://genomediscovery.org or http://newbioideas.com


Amount: $100#

Undisclosed information: How Amla (Emblica officinalis) extract suppresses the expression of Tripeptidyl Peptidase 1 (TPP1)

Satisfaction-guaranteed-if-not-refunded

# Research cooperation

Comments are closed.