Natural product Anti-telomerase cancer therapy: Eriocitrin, a flavonoid commonly found in lemons, suppresses the expression of Tripeptidyl Peptidase 1 (TPP1) and telomerase and inhibits cancer progression via down-regulation of its target gene, 12/November/2016, 7.10 am

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What they say: Introduction: 

The 1989 Nobel prize winner in Chemistry, Prof. Thomas R. Cech and his research team from the BioFrontiers Institute, USA has published a research paper in the 13 December 2012 Nature (492(7428):285-9; and I.F: >42) stating that “The TEL patch of telomere protein TPP1 mediates telomerase recruitment and processivity.”  This study provides mechanistic insights into how TPP1 regulates telomerase function.


What we say: 

In connection with the finding presented above, Dr Boominathan, Founder Director-cum-chief scientist of GBMD, reports that: Natural product Anti-telomerase cancer therapy: Eriocitrin, a flavonoid commonly found in lemonssuppresses the expression of Tripeptidyl Peptidase 1 (TPP1) and telomerase and inhibits cancer progression via down-regulation of its target gene


Significance:

Given that cancer causes the highest economic loss compared to all the known causes of death worldwide, there is an urgent need to find: (i) a cheaper alternative to the existing expensive drugs; (ii) a side-effect-free natural product-based drug; (iii) a way to effectively treat cancers that are resistant to anti-cancer drugs; and (iv) a way to effectively treat and eradicate metastatic progression of cancer.


From Research Findings to Therapeutic opportunity:

Eriocitrin, by decreasing the expression of its target gene, it may suppress the expression of Tripeptidyl Peptidase 1 (TPP1). Remarkably, over 90% human tumors overexpress cellular immortality gene telomerase, suggesting that inhibition of its activity may increase the efficacy of anticancer therapy.

 

Lemon tree

Lemon tree

Figure 1. Pueraria-lobata. Eriocitrin, found in lemons, inhibits human cancer cell proliferation via down-regulation of Tripeptidyl Peptidase 1 (TPP1) and telomerase

Figure 1. Lemon fruits. Eriocitrin, found in lemons, inhibits human cancer cell proliferation via down-regulation of Tripeptidyl Peptidase 1 (TPP1) and telomerase

 

Image result for Eriocitrin

Eriocitrin

Together, this study suggests that pharmacological formulations encompassing Eriocitrin or its analogs may be used to treat human cancers.

 


Idea Proposed/Formulated byDr L Boominathan Ph.D.

CitationBoominathan, L., Natural product Anti-telomerase cancer therapy: Eriocitrin, a flavonoid commonly found in lemonssuppresses the expression of Tripeptidyl Peptidase 1 (TPP1) and telomerase and inhibits cancer progression via down-regulation of its target gene, 12/November/2016, 7.10 am,  Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org

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Amount: $100#

Undisclosed mechanistic insights: How does Eriocitrin suppress the expression of Tripeptidyl Peptidase 1 (TPP1) and telomerase? 

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