Introduction: What they say
A study from the Richard King Mellon Foundation Institute for Pediatric Research, Department of Pediatrics, University of Pittsburgh School of Medicine, Pittsburgh, PA 15224, USA shows that “IL-17 Receptor Signaling in the Lung Epithelium Is Required for Mucosal Chemokine Gradients and Pulmonary Host Defense against K. pneumoniae.” This research paper was published (online) in the 27 October 2016 issue of the journal “Cell Host and microbe” [One of the best research journals in “Infectious biology” with an I.F of 12+] by Prof. Jay K. Kolls, Kong Chen and others.
What we say:
On the foundation of this interesting finding, Dr L Boominathan PhD, Director-cum-chief Scientist of GBMD, reports that: Natural product-based therapy against Pulmonary bacterial pathogens: Rhamnetin, a flavanoid found in Cloves, increases IL-17R and Chemokine CXCL5 expression and protects against infections caused by bacterial pathogen K. pneumoniae via upregulation of its target gene
What is known?
Prof. Jay K Koll’s research team has recently shown that deletion of IL-17R in lung epithelium results in a) impairment of neutrophil recruitment; b) defective bacterial clearance; and c) decreased expression of chemokine CXCL5. They have further shown that intranasal administration of CXCL5 restores neutrophil recruitment and bacterial clearance.
What we say: Research findings:
This study suggests, for the first time, a natural product-based therapy against Pulmonary bacterial pathogens. Rhamnetin, by increasing the expression of its target gene, it may increase the expression of IL-17R expression.
Thereby, it may: (1) increase CXCL5 expression; (2) promote neutrophil recruitment; (3) promote clearance of pulmonary pathogen such as Klebsiella pneumoniae; and (4) strengthen mucosal immunity against pulmonary pathogens.
Thus, pharmacological formulations encompassing “Rhamnetin or its analogues” may be used to treat infections caused by pulmonary pathogen such as Klebsiella pneumoniae.
Idea Proposed/Formulated (with experimental evidence) by: Dr L Boominathan Ph.D.
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Citation: Boominathan, L., Natural product-based therapy against Pulmonary bacterial pathogens: Rhamnetin, a flavanoid found in Cloves, increases IL-17R and Chemokine CXCL5 expression and protects against infections caused by bacterial pathogen K. pneumoniae via upregulation of its target gene, 4/November/2015, 10.56 pm, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org
Undisclosed information: How Rhamnetin increases the expression of IL-17R and CXCL5
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