Natural product-based therapy for Regenerating the lost cardiomyocytes in Myocardial patients: Avicularin, found in Taxillus kaempferi, Polygonum aviculare, among others, increases the expression of ERBB2/Her2 and promotes dedifferentiation of cardiomyocytes via down regulation of its target gene, 11/November/2015, 10.41 pm

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Introduction: What they say

A recent study from the Department of Biological Regulation, Weizmann Institute of Science, Rehovot 76100, Israel shows that “ERBB2 triggers mammalian heart regeneration by promoting cardiomyocyte dedifferentiation and proliferation.” This study was published in the 6 April  2015 issue of the journal “Nature cell biology” (the number 1 journal in “Cell biology” research with an impact factor of 20.761) by Prof Tzahor ED’Uva G, and others.


What we say: 

On the foundation of this interesting finding, Dr L Boominathan PhD, Director-cum-chief Scientist of GBMD, reports that: Natural product-based therapy for Regenerating the lost cardiomyocytes in Myocardial patients: Avicularin, found in Taxillus kaempferi,  Polygonum aviculare, among others, increases the expression of ERBB2/Her2 and promotes dedifferentiation  of cardiomyocytes via down regulation of its target gene


Significance

Given that: (1)  cardiovascular disease is the leading cause of death worldwide; (2) in India, in 2004, 14.6 lakhs deaths (14% of total deaths) were due to ischemic heart disease;  and (3) the global economic cost spent in the treatment of cardiovascular disease in 2011 was little more than 10 billion US dollars, there is an urgent need to find a way to induce regeneration of cardiomyocytes that were lost in Myocardial patients.


From research findings to Therapeutic opportunity: 

This study suggests, for the first time, a Natural product-based cardiac regeneration therapy. Avicularin, by decreasing the expression of its target gene, it may: (1) increase ERBB2/Her2 expression; (2) induce cardiomyocyte (CM) dedifferentiation and proliferation; and (3) cardiomyocyte (CM) redifferentiation and regeneration.  

A

Figure 1. Taxillus kaempferi. Avicularin, found in Taxillus kaempferi,  among others, as indicated below, may promote cardiac dedifferentiation and regeneration via up-regulation of ERRB2/HER2

Rhododendron aureum

Rhododendron aureum

 

Polygonum aviculare

Polygonum aviculare

 

Avicularin

Avicularin

Thus, pharmacological formulations encompassing Avicularin or its analogues may be used to promote cardiomyocyte regeneration following myocardial infarction


Idea Proposed/Formulated (with experimental evidence) by:

Dr L Boominathan Ph.D.

Web: http://genomediscovery.org or newbioideas.com

Terms & Conditions apply http://genomediscovery.org/registration/terms-and-conditions/

Citation: Boominathan, L., Natural product-based therapy for Regenerating the lost cardiomyocytes in Myocardial patients: Avicularin, found in Taxillus kaempferi,  Polygonum aviculare, among others, increases the expression of ERBB2/Her2 and promotes dedifferentiation  of cardiomyocytes via down regulation of its target gene, 11/November/2015, 10.41 pm,  Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org

Courtesy: When you cite drop us a line at info@genomediscovery.org

# Research cooperation


Amount: $ 300

Undisclosed (mechanistic insights) information: How Avicularin increases the expression of  ERBB2/Her2

 guaranteed-to-work1

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