Natural product-based therapy for Regenerating the lost cardiomyocytes in Myocardial patients: Curcumin analog EF24 increases the expression of ERBB2/Her2 and promotes dedifferentiation of cardiomyocytes via down regulation of its target gene, 12/November/2015, 11.06 pm

Anti-inflammatory therapy for upper respiratory tract inflammatory diseases: NQO1 increases the expression of negative regulator of inflammation MyD88(s), inhibits pro-inflammatory mediators in lungs, and alleviates the common respiratory pathogen nontypeable Haemophilus influenzae (NTHi)-exacerbated asthma & chronic obstructive pulmonary disease via up-regulation of its target gene, 12/November/2015, 10.53 pm,
November 12, 2016
Molecular therapy for Myocardial Infarction: miR-380-5p improves myocardial function after myocardial infarction via up-regulation of PNUTS, 11/November/2016, 11.22 pm
November 12, 2016
Show all

Introduction: What they say

A recent study from the Department of Biological Regulation, Weizmann Institute of Science, Rehovot 76100, Israel shows that “ERBB2 triggers mammalian heart regeneration by promoting cardiomyocyte dedifferentiation and proliferation.” This study was published in the 6 April  2015 issue of the journal “Nature cell biology” (the number 1 journal in “Cell biology” research with an impact factor of 20.761) by Prof Tzahor ED’Uva G, and others.


What we say: 

On the foundation of this interesting finding, Dr L Boominathan PhD, Director-cum-chief Scientist of GBMD, reports that: Natural product-based therapy for Regenerating the lost cardiomyocytes in Myocardial patients: Curcumin analog EF24 increases the expression of ERBB2/Her2 and promotes dedifferentiation  of cardiomyocytes via down regulation of its target gene


Significance

Given that: (1)  cardiovascular disease is the leading cause of death worldwide; (2) in India, in 2004, 14.6 lakhs deaths (14% of total deaths) were due to ischemic heart disease;  and (3) the global economic cost spent in the treatment of cardiovascular disease in 2011 was little more than 10 billion US dollars, there is an urgent need to find a way to induce regeneration of cardiomyocytes that were lost in Myocardial patients.


From research findings to Therapeutic opportunity: 

This study suggests, for the first time, a Natural product-based cardiac regeneration therapy. Curcumin analog EF24 , by decreasing the expression of its target gene, it may: (1) increase ERBB2/Her2 expression; (2) induce cardiomyocyte (CM) dedifferentiation and proliferation; and (3) cardiomyocyte (CM) redifferentiation and regeneration.  

Curcumin, one of the main component of Turmeric,

Curcumin analog EF24, one of the main components of Turmeric, may promote cardiac dedifferentiation and regeneration via up-regulation of ERRB2/HER2

Image result for curcumin EF24

Curcumin analog EF24

Thus, pharmacological formulations encompassing Curcumin analog EF24 may be used to promote cardiomyocyte regeneration following myocardial infarction


Idea Proposed/Formulated (with experimental evidence) by:

Dr L Boominathan Ph.D.

Web: http://genomediscovery.org or newbioideas.com

Terms & Conditions apply http://genomediscovery.org/registration/terms-and-conditions/

Citation: Boominathan, L., Natural product-based therapy for Regenerating the lost cardiomyocytes in Myocardial patients: Curcumin analog EF24  increases the expression of ERBB2/Her2 and promotes dedifferentiation  of cardiomyocytes via down regulation of its target gene, 12/November/2015, 11.06 pm,  Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org

Courtesy: When you cite drop us a line at info@genomediscovery.org

# Research cooperation


Amount: $ 100

Undisclosed (mechanistic insights) information: How Curcumin analog EF24  increases the expression of  ERBB2/Her2

 guaranteed-to-work1

Comments are closed.