Natural product-derived anti-ageing therapy: 2,4,5-trihydroxybenzaldehyde (TDB), found in Geum japonicum and Polygonum cuspidatum (PC), also known as Japanese knotweed, increases NMN levels, decreases age-associated weight gain, augments energy metabolism, improves physical activity and insulin sensitivity, promotes healthy lipid profile, and improves eye function via down regulation of its target gene, 29/November/2015, 10.10 am

Molecular therapy for Myocardial Infarction: PPARδ improves myocardial function after myocardial infarction via up-regulation of PNUTS, 29/November/2016, 6.00 am
November 29, 2016
Natural product-derived therapy for tuberculosis: Ganoderma lucidum, a medicinal/herbal mushroom, increases the expression of MKP-1, inhibits TLR2 signalling, secretion of Chemokine CXCL5, and recruitment of polymorphonuclear leukocytes (PMNs), decreases destructive pulmonary inflammation, promotes M. tuberculosis clearance and inhibits pulmonary tuberculosis via up-regulation of its target gene, 29/November/2016, 8.39 pm
November 29, 2016
Show all

Introduction: What they say

A study from Gladstone Institute of Neurological Disease and Department of Neurology, University of California, San Francisco, San Francisco, CA 94158, USA and Department of Developmental Biology, Washington University School of Medicine, Saint Louis, MO 63110, USA shows that Prolonged Administration of Nicotinamide Mononucleotide Mitigates Age-Associated Physiological Decline in Mice. This research paper was published (online) in the 27 October 2016 issue of the journal “Cell Metabolism” [One of the best research journals in Metabolism with an I.F of 17.565+] by Prof. Shin-ichiro Imai, Kathryn F. Mills and others.


What we say:

On the foundation of this interesting finding, Dr L Boominathan PhD, Director-cum-chief Scientist of GBMD, reports that: Natural product-derived anti-ageing therapy: 2,4,5-trihydroxybenzaldehyde (TDB), found in  Geum japonicum and Polygonum cuspidatum (PC), also known as Japanese knotweed,  increases NMN levels, decreases age-associated weight gain, augments energy metabolism, improves physical activity and insulin sensitivity, promotes healthy lipid profile, and improves eye function via down regulation of its target gene

price-300

[easy_payment currency=”USD”]


What is known?

Prof. Shin-ichiro Imai’s research team has recently shown that administering mice with NMN, for a year, results in mitigation of age-associated physiological decline, such as a) increased body weight; b) decreased energy metabolism plus utilization; c) decreased physical activity; d) increased insulin resistance; e) increased lipid profile; f) decreased eye function; g) decreased mitochondrial oxidative metabolism; and i) increased mitonuclear protein imbalance.


From Research findings to Therapeutic opportunity

This study suggests, for the first time, a natural product-based therapy for age-associated physiological decline. 2,4,5-trihydroxybenzaldehyde (TDB), by decreasing the expression of its target gene, it may increase the levels of NAMPT and NMN.

Figure1. 2,4,5-trihydroxybenzaldehyde (TDB), isolated from Polygonum Cuspidatum flowers, increases NMN levels and mitigates age-associated physiological decline.

 Geum japonicum

Figure2. 2,4,5-trihydroxybenzaldehyde (TDB) is also found in Geum japonicum

Thereby, it may: (1) increase plasma NMN levels and tissue NAD+ availability; (2) prevent age-associated weight-gain; (3) enhance energy metabolism and physical activity; (4) increase insulin sensitivity and lipid profiles; (5) prevent age-associated gene expression pattern; (6) augment mitochondrial respiratory capacity; (7) improves eye function; and (8) improve bone mineral density (figure 1).

Thus, pharmacological formulations encompassing 2,4,5-trihydroxybenzaldehyde (TDB) or its analogues or TDB plus any of the known anti-ageing compounds in use may be used to suppress age-associated overall physiological decline; and improve health/life span.


Details of the research findings:

Idea Proposed/Formulated (with experimental evidence) by: Dr L Boominathan Ph.D.

Terms & Conditions apply http://genomediscovery.org/registration/terms-and-conditions/

Amount: $300

Undisclosed mechanistic information: How does 2,4,5-trihydroxybenzaldehyde (TDB) increase the levels of Nampt and NMN?

For purchase and payment details, you may reach us at admin@genomediscovery.org

# Research cooperation


References:

Citation: Boominathan, L., Natural product-derived anti-ageing therapy: 2,4,5-trihydroxybenzaldehyde (TDB), found in  Geum japonicum and Polygonum cuspidatum (PC), also known as Japanese knotweed,  increases NMN levels, decreases age-associated weight gain, augments energy metabolism, improves physical activity and insulin sensitivity, promotes healthy lipid profile, and improves eye function via down regulation of its target gene, 29/November/2015, 10.10 am, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org

Web: http://genomediscovery.org or http://newbioideas.com

Courtesy: When you cite us, drop us a line at admin@genomediscovery.org

Comments are closed.