Natural product Immune enhancement therapy: Cucurbitacin D, found in Trichosanthes kirilowii (Gualou), Phormium tenaxm, and Luffa amara, among others, increases SOX2 expression and promotes innate immunity against bacterial infection via down-regulation of its target gene, 11/November/2016, 8.05 am

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Introduction: What they say: 

A recent study from the Institute of Biophysics, Chinese Academy of Sciences, Beijing, China shows that “Sox2 functions as a sequence-specific DNA sensor in neutrophils to initiate innate immunity against microbial infection.” This study was published in the 2 March 2015 issue of the Journal “Nature Immunology” [the number one journal in immunological research with an impact factor of  24.973] by Drs. Zusen Fan, Xia and others.


What we say: 

On the foundation of this interesting finding, Dr L Boominathan PhD, Director-cum-chief Scientist of GBMD, reports that: Natural product Immune enhancement therapy: Cucurbitacin D, found in Trichosanthes kirilowii (Gualou), Phormium tenaxm, and Luffa amara, among others, increases SOX2 expression and promotes innate immunity against bacterial infection via down-regulation of its target gene. 


From Research Findings to Therapeutic Opportunity:

This study suggests, for the first time, Cucurbitacin D, by decreasing the expression of its target gene, it may : (1) increase the expression of Sox2; (2) increase the ability of Sox2 to recognize bacterial DNA in cytoplasm; and (3) promote innate immunity against bacterial infection. 

Gualou

Figure1. Cucurbitacin D, found in Trichosanthes kirilowii (Gualou), Phormium tenaxm, Luffa amara, among others,  promotes innate immunity against bacterial infection via up-regulation of Sox2

 

phormium-tenax

Phormium tenax

Luffa

Luffa

Image result for Cucurbitacin D

Cucurbitacin D

Together, pharmacological formulations encompassing “Cucurbitacin D or its analogs” may be used to (1) enhance innate immunity against bacterial infection; and (2) promote bacterial resistance. 


Idea Proposed/Formulated byDr L Boominathan Ph.D.

Web: http://genomediscovery.org or http://newbioideas.com

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CitationBoominathan, L., Natural product Immune enhancement therapy: Cucurbitacin D, found in Trichosanthes kirilowii (Gualou), Phormium tenaxm, and Luffa amara, among others, increases SOX2 expression and promotes innate immunity against bacterial infection via down-regulation of its target gene, 11/November/2016, 8.05 am,  Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org

Courtesy: When you cite drop us a line at info@genomediscovery.org

# Research cooperation


Undisclosed information: How Cucurbitacin D: (1) enhances innate immunity against bacterial infection; and (2) promotes bacterial resistance?

Amount: $300

100-guaranteed-to-work-if-not-cash-back

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