Natural product Life-extension therapy: Cucurbitacin D, found in Trichosanthes kirilowii (Gualou), Cucurbita andreana, Phormium tenax, Luffa, among others, inhibits the expression of Ribosomal protein S6 kinase 1 (p70S6 Kinase) and extends mammalian life span, 10/November/2016, 5.47 am

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What they say?

A recent study from the Institute of Healthy Ageing, Centre for Diabetes and Endocrinology, Department of Medicine, University College London, London WC1E 6JJ, UK shows that “Ribosomal protein S6 kinase 1 signaling regulates mammalian life span.” This study was published in the 2 October 2009 issue of the Journal “Science” (I.F: 31.477 ) by Prof Dominic J. Withers, Dr. Selman C and others.


What we say: 

On the foundation of this interesting finding, Dr L Boominathan PhD, Director-cum-chief Scientist of GBMDreports, for the first time, that: Natural product Life-extension therapy: Cucurbitacin D, found in Trichosanthes kirilowii (Gualou), Cucurbita andreana, Phormium tenax, Luffa, among others, inhibits the expression of Ribosomal protein S6 kinase 1 (p70S6 Kinase) and extends mammalian life span


Research findings to Therapeutic opportunity

This study suggests a natural product-based life extension therapy. Cucurbitacin D, by  increasing  the expression of its target gene, it may suppress Ribosomal protein S6 kinase 1 (p70S6 Kinase) expression. Thereby, it may promote: (1) resistance to bone, immune, and motor dysfunction; (2) insulin sensitivity; and (3) longevity.   

Gualou

Figure1. Cucurbitacin D, found in Trichosanthes kirilowii (Gualou), Phormium tenaxm, Luffa amara, among others, extends mammalian lifespan via down-regulation of p70S6 Kinase

 

phormium-tenax

Phormium tenax

Luffa

Luffa

Image result for Cucurbitacin D

Cucurbitacin D

Thus, pharmacological formulations encompassing “Cucurbitacin D or its analogs” can be used to extend the lifespan of an individual.


Idea Proposed/Formulated (with experimental evidence) by:

Dr L Boominathan Ph.D.

Terms & Conditions apply http://genomediscovery.org/registration/terms-and-conditions/

CitationBoominathan, L.,  Natural product Life-extension therapy: Cucurbitacin D, found in Trichosanthes kirilowii (Gualou), Cucurbita andreana, Phormium tenax, Luffa, among others, inhibits the expression of Ribosomal protein S6 kinase 1 (p70S6 Kinase) and extends mammalian life span, 10/November/2016, 5.47 am, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org

Web: http://genomediscovery.org or newbioideas.com

Courtesy: When you cite drop us a line at info@genomediscovery.org


Undisclosed Information: How Cucurbitacin D decreases the expression of p70 S6 Kinase and promotes mammalian life span?

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