Natural product Life-span extension therapy: Amifostine/Ethyol increases life span by suppressing mTOR pathway through up regulation of its target gene, 14/November/2016, 10.02 pm

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What is known:

It has been shown earlier that decreasing the expression/activity of mTOR increases overall mammalian lifespan, suggesting that mTOR inhibitors may function as “longevity promoters”

From research findings to therapeutic opportunity: 

This study suggests, for the first time, that Amifostine/Ethyol, by increasing the expression of its target gene, it may suppress the expression of mTOR. Thereby, it may: (i) increase autophagic flux; (ii) decrease reactive oxygen species; and (iii) increase  the lifespan of an individual. 


Figure1. Amifostine/Ethyol may extend mammalian life span via down regulation of mTOR

Together, this study suggests that pharmacological formulations encompassing Amifostine/Ethyol or its analogues” may function as longevity promoters.

Idea Proposed/Formulated (with experimental evidence) by:

Dr L Boominathan Ph.D.

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CitationBoominathan, L., Natural product Life-span extension therapy: Amifostine/Ethyol increases life span by suppressing mTOR pathway through up regulation of its target gene, 14/November/2016, 10.02 pm,  Genome-2-Bio-Medicine Discovery center (GBMD),

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# Research cooperation

Amount: $200

Undisclosed mechanistic information: How does Amifostine/Ethyol decrease the expression of mTOR?


# Research cooperation

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