Natural product Life-span extension therapy: Plums (Prunus salicina L) extract increases life span by suppressing mTOR pathway through up regulation of its target gene, 22/November/2016, 6.10 am

Anti-telomerase cancer therapy: MiRNA-466g suppresses the expression of Tripeptidyl Peptidase 1 (TPP1) and inhibits cancer progression via down-regulation of its target gene, 21/November/2016, 11.22 pm
November 21, 2016
Natural product therapy for brain repair and Life-span extension: Areca nut extract/Arecoline increases VGF and BDNF expression, promotes Oligodendrocytes (OP) proliferation, triggers myelination on neurons, reverts neural damage, produces anti-depressant like effects, and prolongs lifespan via up-regulation of its target gene, 22/November/2016, 6.57 am
November 22, 2016
Show all

What is known:

It has been shown earlier that decreasing the expression/activity of mTOR increases overall mammalian lifespan, suggesting that mTOR inhibitors may function as “longevity promoters”


From research findings to therapeutic opportunity

This study suggests, for the first time, that Plum extract, by increasing the expression of its target gene, it may suppress the expression of mTOR. Thereby, it may: (i) increase autophagic flux; (ii) decrease reactive oxygen species; and (iii) increase  the lifespan of an individual. 

prunus-salicina-l

Figure1. Plums (Prunus salicina L) extract may extend mammalian life span via down regulation of mTOR

price-50Together, this study suggests that pharmacological formulations encompassing Plum extract or an active compound isolated from it” may function as longevity promoters.


Details of the research findings

Idea Proposed/Formulated (with experimental evidence) by:

Dr L Boominathan Ph.D.

Terms & Conditions apply http://genomediscovery.org/registration/terms-and-conditions/

Amount: $50

Undisclosed mechanistic information: How Plum extract decreases the expression of mTOR?


References:

Web: http://genomediscovery.org or http://newbioideas.com

CitationBoominathan, L., Natural product Life-span extension therapy: Plums (Prunus salicina L) extract  increases life span by suppressing mTOR pathway through up regulation of its target gene, 22/November/2016, 6.10 am,  Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org

Courtesy: When you cite drop us a line at info@genomediscovery.org

# Research cooperation


Comments are closed.