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What is known:

It has been shown earlier that decreasing the expression/activity of mTOR increases overall mammalian lifespan, suggesting that mTOR inhibitors may function as “longevity promoters”

From research findings to therapeutic opportunity

This study suggests, for the first time, that Plum extract, by increasing the expression of its target gene, it may suppress the expression of mTOR. Thereby, it may: (i) increase autophagic flux; (ii) decrease reactive oxygen species; and (iii) increase  the lifespan of an individual. 


Figure1. Plums (Prunus salicina L) extract may extend mammalian life span via down regulation of mTOR

price-50Together, this study suggests that pharmacological formulations encompassing Plum extract or an active compound isolated from it” may function as longevity promoters.

Details of the research findings

Idea Proposed/Formulated (with experimental evidence) by:

Dr L Boominathan Ph.D.

Terms & Conditions apply

Amount: $50

Undisclosed mechanistic information: How Plum extract decreases the expression of mTOR?


Web: or

CitationBoominathan, L., Natural product Life-span extension therapy: Plums (Prunus salicina L) extract  increases life span by suppressing mTOR pathway through up regulation of its target gene, 22/November/2016, 6.10 am,  Genome-2-Bio-Medicine Discovery center (GBMD),

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