What is known:
It has been shown earlier that decreasing the expression/activity of mTOR increases overall mammalian lifespan, suggesting that mTOR inhibitors may function as “longevity promoters”
From research findings to therapeutic opportunity:
This study suggests, for the first time, that Plum extract, by increasing the expression of its target gene, it may suppress the expression of mTOR. Thereby, it may: (i) increase autophagic flux; (ii) decrease reactive oxygen species; and (iii) increase the lifespan of an individual.
Details of the research findings:
Idea Proposed/Formulated (with experimental evidence) by:
Dr L Boominathan Ph.D.
Terms & Conditions apply http://genomediscovery.org/registration/terms-and-conditions/
Undisclosed mechanistic information: How Plum extract decreases the expression of mTOR?
Citation: Boominathan, L., Natural product Life-span extension therapy: Plums (Prunus salicina L) extract increases life span by suppressing mTOR pathway through up regulation of its target gene, 22/November/2016, 6.10 am, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org
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# Research cooperation