Natural product Life-span extension therapy: (+)-Syringaresinol, isolated from Panax ginseng berry, & Prunus mume, among others, increases life span by suppressing mTOR pathway through up regulation of its target gene, 13/November/2016, 11.26 am

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What is known:

It has been shown earlier that decreasing the expression/activity of mTOR increases overall mammalian lifespan, suggesting that mTOR inhibitors may function as “longevity promoters”


From research findings to therapeutic opportunity: 

This study suggests, for the first time, that (+)-Syringaresinol, by increasing the expression of its target gene, it may suppress the expression of mTOR. Thereby, it may: (i) increase autophagic flux; (ii) decrease reactive oxygen species; and (iii) increase  the lifespan of an individual. 

Figure1. (+)-Syringaresinol, isolated from Panax ginseng berry, Prunus mume, as indicated below, may extend mammalian life span via down regulation of mTOR

Prunus mume

Prunus mume

Image result for (-)-syringaresinol

Syringaresinol

Together, this study suggests that pharmacological formulations encompassing (+)-Syringaresinol or its analogues” may function as longevity promoters.


Idea Proposed/Formulated (with experimental evidence) by:

Dr L Boominathan Ph.D.

Web: http://genomediscovery.org or http://newbioideas.com

Terms & Conditions apply http://genomediscovery.org/registration/terms-and-conditions/

CitationBoominathan, L., Natural product Life-span extension therapy: (+)-Syringaresinol, isolated from Panax ginseng berry, & Prunus mume, among others, increases life span by suppressing mTOR pathway through up regulation of its target gene, 13/November/2016, 11.26 am,  Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org

Courtesy: When you cite drop us a line at info@genomediscovery.org

# Research cooperation


Amount: $200

Undisclosed mechanistic information: How does (+)-Syringaresinol decrease the expression of mTOR?

guaranteed-to-work1

# Research cooperation

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