Natural product Lifespan extension therapy: Methyl 3,5-dicaffeoyl quinate (MDQ), found in Kalopanax pictus, Salicornia herbacea L., Aster oharai and Solidago virga-aurea var. gigantean, increases life span via up-regulation of its target gene BubR1, 11/November/2016, 10.04 am

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 What they say: Introduction

A recent study from the Department of Genetics, Paul F. Glenn Laboratories for the Biological Mechanisms of Aging Harvard Medical School, Boston,USA; and Department of Pharmacology, School of Medicine, The University of New South Wales, Australia shows that Sirtuin-2 induces the checkpoint kinase BubR1 to increase lifespan. This study was published in the 1 July  2014 issue of the journal  “EMBO” by Prof Sinclair, North BJ, and others.


What we say

price-100On the foundation of this interesting finding, Dr L Boominathan PhD, Director-cum-chief Scientist of GBMD, reports that:  Natural product Lifespan extension therapy: Methyl 3,5-dicaffeoyl quinate (MDQ), found in Kalopanax pictus, Salicornia herbacea L., Aster oharai and Solidago virga-aurea var. gigantean,increases life span via up-regulation of its target gene BubR1. 


From Research Findings to Therapeutic Opportunity

This study suggests a natural product-based life extension therapy. Methyl 3,5-dicaffeoyl quinate (MDQ), by increasing the expression of its target gene, it may increase the expression of BuBR1. Thereby, it may: (1) delay diseases of aging; (2) slow down aging; and (3) prolong median life span. Thus, pharmacological formulations encompassing“Methyl 3,5-dicaffeoyl quinate (MDQ) or its analogues” may be used to extend the lifespan of an individual. 

Castor-aralia (kalopanax-pictus)

Methyl 3,5-dicaffeoyl quinate (MDQ), found in Castor-aralia (kalopanax-pictus), among others, as indicated below, extends mammalian life span via up regulation of BuBR1

Salicornia herbacea L

Salicornia herbacea L


Details on the research findings

Idea Proposed/Formulated (with experimental evidence) by:

Dr L Boominathan Ph.D.

Amount: $100#

Undisclosed information: How Methyl 3,5-dicaffeoyl quinate (MDQ) increases the expression of BubR1 and extends mammalian life-span

Terms & Conditions apply http://genomediscovery.org/registration/terms-and-conditions/

# Research cooperation


Reference

Web: http://genomediscovery.org or http://newbioideas.com

CitationBoominathan, L., Natural product Lifespan extension therapy: Methyl 3,5-dicaffeoyl quinate (MDQ), found in Kalopanax pictus, Salicornia herbacea L., Aster oharai and Solidago virga-aurea var. gigantean, increases life span via up-regulation of its target gene BubR1, 11/November/2016, 10.04 am,  Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org

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