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 What they say: Introduction: 

A recent study from the Department of Genetics, Paul F. Glenn Laboratories for the Biological Mechanisms of Aging Harvard Medical School, Boston,USA; and Department of Pharmacology, School of Medicine, The University of New South Wales, Australia shows that Sirtuin-2 induces the checkpoint kinase BubR1 to increase lifespan. This study was published in the 1 July  2014 issue of the journal  “EMBO” by Prof Sinclair, North BJ, and others.


What we say: 

On the foundation of this interesting finding, Dr L Boominathan PhD, Director-cum-chief Scientist of GBMD, reports that:  Natural product Lifespan extension therapy: N-methylpyridinium (NMP), one of the constituents of Coffee,  increases life span via up-regulation of its target gene BubR1. 


From Research Findings to Therapeutic Opportunity: 

extends mammalian lifespan via up-regulation of BuBR1

N-methylpyridinium (NMP), one of the constituents of Coffee, extends mammalian lifespan via up-regulation of BuBR1

This study suggests a natural product-based life extension therapy. 

N-methylpyridinium (NMP), by increasing the expression of its target gene, it may increase the expression of BuBR1. Thereby, it may: (1) delay diseases of aging; (2) slow down aging; and (3) prolong median life span. Thus, pharmacological formulations encompassing N-methylpyridinium (NMP) or its analogs may be used to extend the lifespan of an individual. 


Idea Proposed/Formulated byDr L Boominathan Ph.D.

Web: http://genomediscovery.org or http://newbioideas.com

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CitationBoominathan,   Natural product Lifespan extension therapy: N-methylpyridinium (NMP), one of the constituents of Coffee, increases life span via up-regulation of its target gene BubR1, 1/November/2016, 10.33 pm,  Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org

Courtesy: When you cite drop us a line at info@genomediscovery.org


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Undisclosed information: How N-methylpyridinium ion (NMP) increases the expression of BubR1 and extends mammalian life-span

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