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price-100

Introduction: What they say

A study from the Department of Pharmacology, The University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA has reported that “miR-34a blocks osteoporosis and bone metastasis by inhibiting osteoclastogenesis and Tgif2.”

This study was published in the June 25, 2014 Nature  [I.F >42] by Prof. Wan Y, Krzeszinski and others from  the Department of Pharmacology, The University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA.


What we say:

On the foundation of this interesting finding, Dr L Boominathan, Director-cum-chief Scientist of GBMD, reports here that: Natural product therapy for Bone disorders:  Cucurbitacin E, found abundantly in Watermelons,  inhibits the expression of Tgif2 and suppresses osteoporosis and bone metastasis via up-regulation of its target gene.


From Research findings to Therapeutic utility

Cucurbitacin E, by up-regulating its target gene, it may suppress the expression of Tgif2. Thereby, it may inhibit the progression of Osteoporosis and bone metastasis. Thus, pharmacological formulations encompassing “Cucurbitacin E or its analogues” can be used to inhibit osteoporosis and bone metastasis.

Watermelons. Figure 1 Cucurbitacin E, found abundantly in Watermelons, inhibits pulmonary tuberculosis via down-regulation of (Toll-like receptor-TLR) TLR-2 and Chemokine CXCL5 and up-regulation of phosphatase MKP-1

Figure 1 Cucurbitacin E, found abundantly in Watermelons, inhibits the progression of Osteoporosis and bone metastasis via down regulation of Tgif2

Cucurbitacin E

Watermelon

Watermelons


Details of the research findings

Undisclosed information: How   Cucurbitacin E suppresses the expression of Tgif2

Amount: $100#

Idea Formulated (with experimental evidence) by: Dr L Boominathan PhD

Terms & Conditions apply http://genomediscovery.org/registration/terms-and-conditions/

                             #Research cooperation


 Reference:

CitationBoominathan, L., Natural product therapy for Bone disorders: Cucurbitacin E, found abundantly in Watermelons,  inhibits the expression of Tgif2 and suppresses osteoporosis and bone metastasis via up-regulation of its target gene, 16/November/2016, 6.05 pm., Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org

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Web: http://genomediscovery.org or http://newbioideas.com

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