Natural product therapy for KRAS-mutant lung cancer: Epigallocatechin gallate, one of the main components of Green tea, decreases the expression of XPO1, increases the level of NFKBIA, inhibits NFKB transcriptional activity and suppresses the progression of KRAS-mutant lung cancer via up regulation of its target gene, 13/November/2016, 9.20 am

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What they say: 

A recent study from the Department of Cell Biology, University of Texas Southwestern Medical Center, Texas 75390, USA shows that XPO1 can be pharmacologically targeted in KRAS-mutant lung cancer. This study was published in the 28 September 2016 issue of Nature by Prof Michael A.White, Kim, and others.


What we say: 

On the foundation of this interesting finding, Dr L Boominathan PhD, Director-cum-chief Scientist of GBMD, reports that: Natural product therapy for KRAS-mutant lung cancer: Epigallocatechin gallate  decreases the expression of XPO1, increases the level of NFKBIA, inhibits NFKB transcriptional activity and suppresses the progression of KRAS-mutant lung cancer via up regulation of its target gene


Significance:

Given that: (1) 20-30% of people with lung cancer have mutations in k-ras gene; (2) out of 1.82 million people diagnosed with lung cancer in 2012, 1.56 million people died; (3) most of the k-ras mutation-containing lung tumors are not amenable to radiation therapy; (4) there are no effective anti-ras therapy available at present; (5) lung cancer is one of the most frequent cancer in men; (6) lung cancer is more common in developed countries than in developing countries; and (7) the global economic cost spent for lung cancer treatment is enormous, there is an urgent need to find: (a) a newer and effective treatment for K-ras mutated lung cancers; (b) a cheaper alternative to the existing expensive non-specific drugs; and (c) a Natural product-based side-effect-free drug.


What is known?

Prof. Michael A. White’s research team has recently shown that inhibition of XPO expression in lung cancer inhibits the progression of K-ras mutated lung cancer through down-regulation of NFKB transcriptional activity.


From Research findings to Therapeutic opportunity: 

On the foundation of this interesting finding, this study suggests a Natural product-based anti-cancer therapy for K-ras mutated human cancers. Epigallocatechin gallate, by increasing the expression of its target gene, it may decrease the expression of XPO1.

Green tea extract slows down aging and increases median lifespan via up-regulation of BuBR1

Green tea functions as an anti-cancer agent against Kras-mutated lung cancers

Green tea leaves

Figure 1 Green tea leaves.     Epigallocatechin gallate, one of the main components of Green tea leaves extract, suppresses progression of Kras-mutated human cancers via down regulation of XPO1

Image result for Epigallocatechin-3-gallate

Epigallocatechin-3-gallate

Thereby, it may: (1) increase the levels of NFKBIA, (2) inhibit NFKB transcriptional activity; and (3) suppress the progression of KRAS-mutant lung cancer. Thus, by treating lung cancer patients with Epigallocatechin gallate, one may prevent the progression of Kras-mediated lung cancer.

Together, this study suggests that pharmacological formulations encompassing “Epigallocatechin gallate or its analogues”  may be used to inhibit the progression of Kras-mediated lung cancer.


Idea Proposed/Formulated by: Dr L Boominathan Ph.D.

Web: http://genomediscovery.org or newbioideas.com 

Citation: Boominathan, L., Natural product therapy for KRAS-mutant lung cancer: Epigallocatechin gallate, one of the main components of Green tea, decreases the expression of XPO1, increases the level of NFKBIA, inhibits NFKB transcriptional activity and suppresses the progression of KRAS-mutant lung cancer via up regulation of its target gene, 13/November/2016, 9.20 am, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org

Courtesy: When you cite drop us a line at info@genomediscovery.org

Terms & Conditions apply http://genomediscovery.org/registration/terms-and-conditions/

# Research cooperation


Undisclosed mechanistic information: How Epigallocatechin gallate decreases the expression of XPO1?

Amount: $200#

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