Natural product therapy for Myocardial Infarction: N-methylpyridinium (NMP), One of the constituents of Coffee, improves myocardial function after myocardial infarction via up regulation of PNUTS/PPP1R10 (Serine/threonine-protein phosphatase 1 regulatory subunit 10), 2/November/2016, 5.43 am

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What they say: 

A recent study from the Institute for Cardiovascular Regeneration, Centre of Molecular Medicine, Frankfurt, Germany shows that “MicroRNA-34a regulates cardiac ageing and function.” This study was published in the 7 March  2013 issue of Nature  by Prof Dimmler, Boon, and others.


What we say: 

On the foundation of this interesting finding, Dr L Boominathan PhD, Director-cum-chief Scientist of GBMD, reports that: Natural product therapy for Myocardial Infarction: N-methylpyridinium (NMP), One of the constituents of Coffee,  improves myocardial function after myocardial infarction via  up regulation of PNUTS/PPP1R10 (Serine/threonine-protein phosphatase 1 regulatory subunit 10)


Significance:

Given that: (1)  cardiovascular disease is the leading cause of death worldwide; (2) in India, in 2004, 14.6 lakhs deaths (14% of total deaths) were due to ischemic heart disease; and (3) the global economic cost spent in the treatment of cardiovascular disease in 2011 was little more than 10 billion US dollars, there is an urgent need to find: (i)  a way to induce regeneration of adult cardiomyocytes that were lost in Myocardial patients; (ii) a cheaper alternative to the existing expensive drugs; and (iii) a side-effect-free drug.


From Research Findings to Therapeutic Opportunity: 

This study suggests a natural product-based cardiac regeneration therapy. N-methylpyridinium (NMP), by increasing the expression of its target gene, it may increase the expression of PNUTS/PPP1R10. Thereby, it may: (1) inhibit DNA damage responses, (2) inhibit telomere shortening; and (3) promote cardiomyocyte survival/regeneration.

extends mammalian lifespan via up-regulation of BuBR1

N-methylpyridinium (NMP) promotes Cardiomyocyte survival via up-regulation of PNUTS/PPP1R10

Thus, by treating myocardial patients with N-methylpyridinium (NMP), one may prevent ageing-associated (or, stress-associated) decline in cardiac function. Together, this study suggests that pharmacological formulations encompassing N-methylpyridinium (NMP) or its analogs  may be used to improve cardiac function after myocardial infarction.  


Idea Proposed/Formulated (with factual evidence) byDr L Boominathan Ph.D.

Web:http://genomediscovery.org or http://newbioideas.com

To citeBoominathan, L.,  Natural product therapy for Myocardial Infarction: N-methylpyridinium (NMP), One of the constituents of Coffee,  improves myocardial function after myocardial infarction via  up regulation of PNUTS/PPP1R10 (Serine/threonine-protein phosphatase 1 regulatory subunit 10), 2/November/2016, 5.43 am,  Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org

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Undisclosed information: How  N-methylpyridinium (NMP) increases the expression of PNUTS/PPP1R10

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