Natural product therapy for Myocardial Infarction: Puerarin, an isoflavone found in Pueraria (Radix puerariae), improves myocardial function after myocardial infarction via up-regulation of PNUTS, 20/November/2016, 8.24 am

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What they say

A recent study from the Institute for Cardiovascular Regeneration, Centre of Molecular Medicine, Frankfurt, Germany shows that “MicroRNA-34a regulates cardiac ageing and function.” This study was published in the 7 March  2013 issue of Nature  by Prof Dimmler, Boon, and others.


What we say

On the foundation of this interesting finding, Dr L Boominathan PhD, Director-cum-chief Scientist of GBMD, reports that: Natural product therapy for Myocardial Infarction: Puerarin, an isoflavone found in Pueraria (Radix puerariae), improves myocardial function after myocardial infarction via  up-regulation of PNUTS

price-100


Significance:

Given that: (1)  cardiovascular disease is the leading cause of death worldwide; (2) in India, in 2004, 14.6 lakhs deaths (14% of total deaths) were due to ischemic heart disease; and (3) the global economic cost spent in the treatment of cardiovascular disease in 2011 was little more than 10 billion US dollars, there is an urgent need to find: (i)  a way to induce regeneration of adult cardiomyocytes that were lost in Myocardial patients; (ii) a cheaper alternative to the existing expensive drugs; and (iii) a side-effect-free drug.


From Research Findings to Therapeutic Opportunity

This study suggests a natural product-based cardiac regeneration therapy. Puerarin, by increasing the expression of its target gene, it may increase the expression of PNUTS. Thereby, it may: (1) inhibit DNA damage responses, (2) inhibit telomere shortening; and (3) promote cardiomyocyte survival/regeneration.

Purarin-isolated-from-kudzu-pueraria-radix-puerariae

Radix puerariae (Kudzu)

puerarin-isolated-from-pueraria-radix-puerariae-kudzu-plant

Puerarin, isolated from Gegen(Pueraria root), promotes Cardiomyocyte survival and protects against myocardial infarction via up-regulation of PNUTS

Puerarin

Puerarin

Thus, by treating myocardial patients with Puerarin, one may prevent ageing-associated (or, stress-associated) decline in cardiac function. Together, this study suggests that pharmacological formulations encompassing Puerarin or its analogues”  may be used to improve cardiac function after myocardial infarction.  


Details of the research findings

Idea Proposed/Formulated (with experimental evidence) by:

Dr L Boominathan Ph.D.

Terms & Conditions apply http://genomediscovery.org/registration/terms-and-conditions/

Undisclosed information: How  Puerarin increases the expression of PNUTS

Amount: $100#

# Research cooperation


References:

Web:http://genomediscovery.org or http://newbioideas.com

To citeBoominathan, L.,  Natural product therapy for Myocardial Infarction: Puerarin, an isoflavone found in Pueraria (Radix puerariae), improves myocardial function after myocardial infarction via  up-regulation of PNUTS, 20/November/2016, 8.24 am,  Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org

Courtesy: When you cite drop us a line at info@genomediscovery.org


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