Natural product therapy for NIDDM: Avicularin, found in Polygonum aviculare, Rhododendron aureum and Taxillus kaempferi, inhibits gluconeogenesis and hyperglycemia via up regulation of Cyclin D1, Genome-2-Bio-Medicine Discovery center (GBMD), 8/November/2016, 1.24 pm

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What they say: 

A study from the Department of Cancer Biology, Dana-Farber Cancer Institute;  Department of Cell Biology, Harvard Medical School, USA; and others shows that Cyclin D1–Cdk4 controls glucose metabolism independently of cell cycle progression.” This study was published in the June 26, 2014 Nature [One of the best journals in Science with an I.F  of 38.138] by ProfPuigserver, Lee and others.


What we say: 

On the foundation of this interesting finding, Dr L Boominathan, Director-cum-chief Scientist of GBMD, reports here that: Natural product therapy for NIDDM: Avicularin, found in Polygonum aviculare, Rhododendron aureum and Taxillus kaempferi, inhibits gluconeogenesis and hyperglycemia via up regulation of Cyclin D1.


Significance: 

Given that: (1)  more than 387 million people worldwide are affected by Diabetes mellitus (DM); (2) the life-long painful injection/drug treatment is required to treat DM; (3) the global economic cost spent for diabetes treatment in 2014 was little more than 600 billion US dollars, there is an urgent need to find: (i) a way to induce regeneration of adult β-cells that were lost in DM; (ii) a way to increase insulin sensitivity in obese individuals; (iii) a cheaper alternative to the existing expensive weight-loss drugs; (iv) a side-effect-free natural product-based drug; and (v) a way to cure, not just treat, diabetes.


From Research Findings to Therapeutic opportunity: 

I have published earlier that natural product Avicularin may prevent ageing-associated (or, stress-associated) decline in cardiac function via up regulation of pro-survival protein PNUTS. 

This study suggests that Avicularin, by down regulating its target gene, it may increase the expression of cell cycle protein Cyclin-D1. Thereby, it may inhibit gluconeogenesis and hyperglycemia.

Avicularin promotes myocardial survival and prevents myocardial infarction via up-regualtion of PNUTS//PPP1R10

Figure 1. Taxillus kaempferi. Avicularin, found in Taxillus kaempferi,  among others, as indicated below, may inhibit gluconeogenesis and hyperglycemia via up regulation of Cyclin D1

Rhododendron aureum

Rhododendron aureum

 

Polygonum aviculare

Polygonum aviculare

 

Avicularin

Avicularin

Together, this study suggests that pharmacological formulations encompassing “Avicularin or its analogues”  may be used in the treatment of NIDDM.


Idea Proposed/Formulated (with experimental evidence) by:

Dr L Boominathan Ph.D.

Web: http://genomediscovery.org or http://newbioideas.com

Terms & Conditions apply http://genomediscovery.org/registration/terms-and-conditions/

CitationBoominathan, L., Natural product therapy for NIDDM: Avicularin, found in Polygonum aviculare, Rhododendron aureum and Taxillus kaempferi, inhibits gluconeogenesis and hyperglycemia via up regulation of Cyclin D1, Genome-2-Bio-Medicine Discovery center (GBMD), 8/November/2016, 1.24 pm.,  http://genomediscovery.org 

Courtesy: When you cite drop us a line at info@genomediscovery.org

# Research cooperation


Amount: $100#

Undisclosed information: How Avicularin increases the expression of Cyclin D1?

100-guaranteed-to-work-if-not-cash-back

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