What they say:
A study from the Department of Cancer Biology, Dana-Farber Cancer Institute; Department of Cell Biology, Harvard Medical School, USA; and others shows that “Cyclin D1–Cdk4 controls glucose metabolism independently of cell cycle progression.” This study was published in the June 26, 2014 Nature [One of the best journals in Science with an I.F of 38.138] by Prof. Puigserver, Lee and others.
What we say:
On the foundation of this interesting finding, Dr L Boominathan, Director-cum-chief Scientist of GBMD, reports here that: Natural product therapy for NIDDM: Avicularin, found in Polygonum aviculare, Rhododendron aureum and Taxillus kaempferi, inhibits gluconeogenesis and hyperglycemia via up regulation of Cyclin D1.
Given that: (1) more than 387 million people worldwide are affected by Diabetes mellitus (DM); (2) the life-long painful injection/drug treatment is required to treat DM; (3) the global economic cost spent for diabetes treatment in 2014 was little more than 600 billion US dollars, there is an urgent need to find: (i) a way to induce regeneration of adult β-cells that were lost in DM; (ii) a way to increase insulin sensitivity in obese individuals; (iii) a cheaper alternative to the existing expensive weight-loss drugs; (iv) a side-effect-free natural product-based drug; and (v) a way to cure, not just treat, diabetes.
From Research Findings to Therapeutic opportunity:
I have published earlier that natural product Avicularin may prevent ageing-associated (or, stress-associated) decline in cardiac function via up regulation of pro-survival protein PNUTS.
This study suggests that Avicularin, by down regulating its target gene, it may increase the expression of cell cycle protein Cyclin-D1. Thereby, it may inhibit gluconeogenesis and hyperglycemia.
Together, this study suggests that pharmacological formulations encompassing “Avicularin or its analogues” may be used in the treatment of NIDDM.
Idea Proposed/Formulated (with experimental evidence) by:
Dr L Boominathan Ph.D.
Terms & Conditions apply http://genomediscovery.org/registration/terms-and-conditions/
Citation: Boominathan, L., Natural product therapy for NIDDM: Avicularin, found in Polygonum aviculare, Rhododendron aureum and Taxillus kaempferi, inhibits gluconeogenesis and hyperglycemia via up regulation of Cyclin D1, Genome-2-Bio-Medicine Discovery center (GBMD), 8/November/2016, 1.24 pm., http://genomediscovery.org
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# Research cooperation
Undisclosed information: How Avicularin increases the expression of Cyclin D1?