Natural product-based therapy for Cardiomyopathy: Apple extract induces the expression of Trbp/miR-208, restores the balance between slow- and fast-twitch myofiber proteins and alleviates Cardiomyopathy via up regulation of its target gene, 17/November/2016, 2.24 pm
Introduction: What they say: A study from the Department of Cardiology, Boston Children’s Hospital, Harvard Medical School, Boston, Massachusetts, USA; and Harvard Stem Cell Institute, Harvard University, Cambridge, Massachusetts, USA shows that “Trbp regulates heart function through microRNA-mediated Sox6 repression.“This study was published in the 2 June 2015 issue of the journal “Nature Genetics” (the number 1 research journal in […]
Natural product therapy for glucose homeostasis and TIIDM: Oleic acid, found in Safflower, olive, canola, Hazelnut, sunflower oils, Avacados, almond and sunflower among others, increases IKKß and XBP1s activity, decreases the levels of tumor suppressor/stress-responsive proteins, such as PDCD4, and PTEN, reduces ER stress, improves insulin sensitivity, promotes glucose homeostasis and prevents the progression of TIIDM via up regulation of its target gene, 17/November/2015, 8.30 am
What they say: A study from the Division of Endocrinology, Boston Children’s Hospital, Harvard Medical School, Boston, MA 02130, USA; Laboratory of Gene Regulation and Signal Transduction, Department of Pharmacology, School of Medicine, University of California, San Diego, 9500 Gilman Drive, San Diego, CA 92093, USA; and Department of Pathology, School of Medicine, University of […]
Natural product-based PD-1 pathway blockade for Human cancer therapy: Ginsenoside, isolated from Ginseng herb, inhibits the expression of co-inhibitory receptor PD-1 on Antigen- Specific T-cells, increases the production of cytokines by tumor-infiltrating lymphocytes (TIL), and draining lymph nodes and augments anti-tumor activity via down-regulation of its target gene, 17/November/2016, 7.18 am
Introduction:What they say: A recent study from Division of Infectious Diseases, School of Medicine, Johns Hopkins University, Baltimore, MD 21218, United States shows that “TGF-β1-Mediated Smad3 Enhances PD-1 Expression on Antigen-Specific T Cells in Cancer.” This study was published in the 28 September 2016 issue of Cancer Discovery (one of the best journals in Cancer […]
Natural product therapy for Breast Cancer: Hyperoside, found in Drosera Rotundifolia and Common self-heal, increases the level of tumor suppressor p53, decreases the expression of metastasis promoter Snail1, inhibits the proliferation of tumor-initiating cells, suppresses the progression of metastatic breast cancer, and supports tumor relapse-free survival in breast cancer patients, 17/November/2015, 6.55 am
Introduction: What they say: A study from the Division of Molecular Medicine and Genetics, Department of Internal Medicine, The Life Sciences Institute, University of Michigan, Ann Arbor, Michigan 48109, USA shows that “Snail1-dependent p53 repression regulates expansion and activity of tumour-initiating cells in breast cancer” This study was published in the 17 October 2016 issue […]
Molecular therapy for Regenerating the lost pancreatic β-cells in Diabetic patients: miR-542-5p promotes an insulin-sensitized state via up-regulation of reprogramming protein Lin28, 17/November/2016, 6.34 am
Introduction: What they say: A study from the Stem Cell Transplantation Program, Division of Pediatric Hematology/Oncology, Boston Children’s Hospital and Dana-Farber Cancer Institute, Boston, Massachusetts, USA shows that “The Lin28/let-7 axis regulates glucose metabolism.” This study was published in the 30 September 2011 issue of the Journal “Cell” [One of the best journals in Biological sciences with an I.F of […]
Natural product Lifespan extension therapy: Methyl 3,5-dicaffeoyl quinate (MDQ), found in Kalopanax pictus, Salicornia herbacea L., Aster oharai and Solidago virga-aurea var. gigantean, increases life span via up-regulation of its target gene BubR1, 11/November/2016, 10.04 am
What they say: Introduction: A recent study from the Department of Genetics, Paul F. Glenn Laboratories for the Biological Mechanisms of Aging Harvard Medical School, Boston,USA; and Department of Pharmacology, School of Medicine, The University of New South Wales, Australia shows that Sirtuin-2 induces the checkpoint kinase BubR1 to increase lifespan. This study was published in the 1 July 2014 issue of the journal “EMBO” by Prof […]
