Monthly Archives: December 2016

Molecular therapy for Human Leukemias: LRRC4/NGL-2 (Leucine rich repeat containing 4/Netrin-G ligand-2) suppresses B-Cell and myeloid leukemias via up regulation of the tumor suppressor IRF4, 31/December/2016, 12.16 pm

Introduction: What they say Noble laureate in Physiology/Medicine (1975) Prof. David Baltimore, from California Institute of Technology, California, USA, had reported in the July 8, 2014 issue of the Journal “Blood” that: “Dual mechanisms by which MiR-125b represses IRF4 to induce myeloid/B-cell leukemias.”  What we say: On the foundation of this … Continue reading

Posted in Ideas | Comments Off on Molecular therapy for Human Leukemias: LRRC4/NGL-2 (Leucine rich repeat containing 4/Netrin-G ligand-2) suppresses B-Cell and myeloid leukemias via up regulation of the tumor suppressor IRF4, 31/December/2016, 12.16 pm

Natural product-derived regenerative therapy for improving muscle repair and strength in the elderly: γ-Bisabolene, found in Cardamom, cubeb, lemon and oregano, decreases the expression of HOXA9, increases skeletal muscle regeneration and improves muscle stem cells function and repair via up regulation of its target genes, 31/December/2016, 11.56 pm

Introduction: What they say A study from Faculty of Medicine, Friedrich-Schiller-University, Germany shows that “Epigenetic stress responses induce muscle stem-cell ageing by Hoxa9 developmental signals.” This research paper was published in the 30 November 2016 issue of the journal “Nature” … Continue reading

Posted in Ideas | Comments Off on Natural product-derived regenerative therapy for improving muscle repair and strength in the elderly: γ-Bisabolene, found in Cardamom, cubeb, lemon and oregano, decreases the expression of HOXA9, increases skeletal muscle regeneration and improves muscle stem cells function and repair via up regulation of its target genes, 31/December/2016, 11.56 pm

Cardiac rejuvenation therapy: Secreted protein acidic and rich in cysteine (SPARC/osteonectin/BM-40) suppresses tumor suppressor INK4a/p16 expression, and inhibits dilated cardiomyopathy and heart failure via up regulation of its target gene, 31/December/2016, 11.25 am

Introduction: What they say A recent study from the Stem Cell Aging Group, Centro Nacional de Investigaciones Cardiovasculares, E-28029 Madrid, Spain shows that “Bmi1 limits dilated cardiomyopathy and heart failure by inhibiting cardiac senescence.” This study was published in the … Continue reading

Posted in Ideas | Comments Off on Cardiac rejuvenation therapy: Secreted protein acidic and rich in cysteine (SPARC/osteonectin/BM-40) suppresses tumor suppressor INK4a/p16 expression, and inhibits dilated cardiomyopathy and heart failure via up regulation of its target gene, 31/December/2016, 11.25 am

Natural product-derived therapy for Human Leukemias: Ginsenoside, one of components in American ginseng herb, found in stem of Caulis clematidis armandii and Hibiscus ficulneus, suppresses B-Cell and myeloid leukemias via up regulation of the tumor suppressor IRF4, 30/December/2016, 10.28 am

Introduction: What they say Noble laureate in Physiology/Medicine (1975) Prof. David Baltimore, from California Institute of Technology, California, USA, had reported in the July 8, 2014 issue of the Journal “Blood” that: “Dual mechanisms by which MiR-125b represses IRF4 to induce myeloid/B-cell leukemias.”  What we say: On the foundation of this … Continue reading

Posted in Ideas | Comments Off on Natural product-derived therapy for Human Leukemias: Ginsenoside, one of components in American ginseng herb, found in stem of Caulis clematidis armandii and Hibiscus ficulneus, suppresses B-Cell and myeloid leukemias via up regulation of the tumor suppressor IRF4, 30/December/2016, 10.28 am

Anti-telomerase cancer therapy: LRRC4/NGL-2 (Leucine rich repeat containing 4/Netrin-G ligand-2) suppresses the expression of Tripeptidyl Peptidase 1 (TPP1) and inhibits cancer progression via down-regulation of it target gene, 30/December/2016, 9.43 am

Introduction: What they say:   The 1989 Nobel prize winner in Chemistry, Prof. Thomas R. Cech from the BioFrontiers Institute, USA has published a research paper in the 13 December 2012 issue of the Nature journal (492(7428):285-9; and I.F: >42) stating that “The TEL patch of telomere protein TPP1 mediates telomerase recruitment and processivity.”  This study provides mechanistic insights into how … Continue reading

Posted in Ideas | Comments Off on Anti-telomerase cancer therapy: LRRC4/NGL-2 (Leucine rich repeat containing 4/Netrin-G ligand-2) suppresses the expression of Tripeptidyl Peptidase 1 (TPP1) and inhibits cancer progression via down-regulation of it target gene, 30/December/2016, 9.43 am

Natural product-derived Cardiac rejuvenation therapy: Kaempferol, found in Allium cepa, Aloe vera, Coccinia grandis, Moringa oleifera, & Rosmarinus officinalis among others, suppresses tumor suppressor INK4a/p16 expression, and inhibits dilated cardiomyopathy and heart failure via up regulation of its target gene, 30/December/2016, 7.15 am

Introduction: What they say A recent study from the Stem Cell Aging Group, Centro Nacional de Investigaciones Cardiovasculares, E-28029 Madrid, Spain shows that “Bmi1 limits dilated cardiomyopathy and heart failure by inhibiting cardiac senescence.” This study was published in the … Continue reading

Posted in Ideas | Comments Off on Natural product-derived Cardiac rejuvenation therapy: Kaempferol, found in Allium cepa, Aloe vera, Coccinia grandis, Moringa oleifera, & Rosmarinus officinalis among others, suppresses tumor suppressor INK4a/p16 expression, and inhibits dilated cardiomyopathy and heart failure via up regulation of its target gene, 30/December/2016, 7.15 am

Life-extension therapy: PAPD5 (Poly(A) RNA Polymerase D5, Non-Canonical) inhibits the expression of Ribosomal protein S6 kinase 1 (p70S6 Kinase) and extends mammalian life span, 29/December/2016, 10. 54 pm

What they say? A recent study from the Institute of Healthy Ageing, Centre for Diabetes and Endocrinology, Department of Medicine, University College London, London WC1E 6JJ, UK shows that “Ribosomal protein S6 kinase 1 signaling regulates mammalian life span.” This study was published in … Continue reading

Posted in Ideas | Comments Off on Life-extension therapy: PAPD5 (Poly(A) RNA Polymerase D5, Non-Canonical) inhibits the expression of Ribosomal protein S6 kinase 1 (p70S6 Kinase) and extends mammalian life span, 29/December/2016, 10. 54 pm

Molecular therapy for Myocardial Infarction: Ambrisentan, a drug used in the treatment of Pulmonary hypertension, inhibits DNA damage responses, increases telomerase expression, inhibits telomere shortening, and promotes cardiomyocyte survival after myocardial infarction via up-regulation of PNUTS, 29/December/2016, 10.22 pm

What they say:  A recent study from the Institute for Cardiovascular Regeneration, Centre of Molecular Medicine, Frankfurt, Germany shows that “MicroRNA-34a regulates cardiac ageing and function.” This study was published in the 7 March  2013 issue of Nature  by Prof Dimmler, Boon, and others. What we say:  On the foundation of this interesting finding, Dr L Boominathan … Continue reading

Posted in Ideas | Comments Off on Molecular therapy for Myocardial Infarction: Ambrisentan, a drug used in the treatment of Pulmonary hypertension, inhibits DNA damage responses, increases telomerase expression, inhibits telomere shortening, and promotes cardiomyocyte survival after myocardial infarction via up-regulation of PNUTS, 29/December/2016, 10.22 pm

Cardiac rejuvenation therapy: Caveolin-1 (CAV1) suppresses tumor suppressor INK4a/p16 expression, and inhibits dilated cardiomyopathy and heart failure via up regulation of its target gene, 29/December/2016, 7.35 pm

Introduction: What they say A recent study from the Stem Cell Aging Group, Centro Nacional de Investigaciones Cardiovasculares, E-28029 Madrid, Spain shows that “Bmi1 limits dilated cardiomyopathy and heart failure by inhibiting cardiac senescence.” This study was published in the … Continue reading

Posted in Ideas | Comments Off on Cardiac rejuvenation therapy: Caveolin-1 (CAV1) suppresses tumor suppressor INK4a/p16 expression, and inhibits dilated cardiomyopathy and heart failure via up regulation of its target gene, 29/December/2016, 7.35 pm

Therapeutic insights into “awakening the sleeping/cancer-protecting angels” in mutant p53-expressing human tumors: Physcion 8-O-β-glucopyranoside, a major ingredient isolated from Radix et Rhizoma Rhei and and Rhubarb, increases the expression of tumor suppressor p53 homologue TA-p73/p63, PTEN, TPM1, TIMP3, BTG2, PDCD4, SPRY1/2 and CCM1/KRIT1 and induces regression of p53-mutated human tumors via down regulation of its target gene, 29/December/2016, 11.04 pm

From Significance of the study to Public health relevance: Given that: (1) Cancer suppressor p53 is mutated in more than 50% of human cancers of different tissue origin; (2) p53 pathway is altered in about 80% of tumors.; (3) our … Continue reading

Posted in Ideas | Comments Off on Therapeutic insights into “awakening the sleeping/cancer-protecting angels” in mutant p53-expressing human tumors: Physcion 8-O-β-glucopyranoside, a major ingredient isolated from Radix et Rhizoma Rhei and and Rhubarb, increases the expression of tumor suppressor p53 homologue TA-p73/p63, PTEN, TPM1, TIMP3, BTG2, PDCD4, SPRY1/2 and CCM1/KRIT1 and induces regression of p53-mutated human tumors via down regulation of its target gene, 29/December/2016, 11.04 pm

Natural product-derived Life-extension therapy: Isoliquiritigenin, isolated from Licorice (Glycyrrhiza glabra), inhibits the expression of Ribosomal protein S6 kinase 1 (p70S6 Kinase) and extends mammalian life span, 28/December/2016, 10. 48 pm

What they say? A recent study from the Institute of Healthy Ageing, Centre for Diabetes and Endocrinology, Department of Medicine, University College London, London WC1E 6JJ, UK shows that “Ribosomal protein S6 kinase 1 signaling regulates mammalian life span.” This study was published in … Continue reading

Posted in Ideas | Comments Off on Natural product-derived Life-extension therapy: Isoliquiritigenin, isolated from Licorice (Glycyrrhiza glabra), inhibits the expression of Ribosomal protein S6 kinase 1 (p70S6 Kinase) and extends mammalian life span, 28/December/2016, 10. 48 pm

Molecular therapy for Myocardial Infarction: Methazolamide, a carbonic anhydrase inhibitor used in the treatment of glaucoma, inhibits DNA damage responses, increases telomerase expression, inhibits telomere shortening, and promotes cardiomyocyte survival after myocardial infarction via up-regulation of PNUTS, 28/December/2016, 6.43 pm

What they say:  A recent study from the Institute for Cardiovascular Regeneration, Centre of Molecular Medicine, Frankfurt, Germany shows that “MicroRNA-34a regulates cardiac ageing and function.” This study was published in the 7 March  2013 issue of Nature  by Prof Dimmler, Boon, and others. What we say:  On the foundation of this interesting finding, Dr L Boominathan … Continue reading

Posted in Ideas | Comments Off on Molecular therapy for Myocardial Infarction: Methazolamide, a carbonic anhydrase inhibitor used in the treatment of glaucoma, inhibits DNA damage responses, increases telomerase expression, inhibits telomere shortening, and promotes cardiomyocyte survival after myocardial infarction via up-regulation of PNUTS, 28/December/2016, 6.43 pm

Therapeutic insights into “awakening the sleeping/cancer-protecting angels” in mutant p53-expressing human tumors: Paeoniflorin, a natural compound isolated from Paeonia lactiflora pall and Paeonia veitchii Lynch, increases the expression of tumor suppressor p53 homologue TA-p73/p63, PTEN, TPM1, TIMP3, BTG2, PDCD4, SPRY1/2 and CCM1/KRIT1 and induces regression of p53-mutated human tumors via down regulation of its target gene, 28/December/2016, 6.30 pm

From Significance of the study to Public health relevance: Given that: (1) Cancer suppressor p53 is mutated in more than 50% of human cancers of different tissue origin; (2) p53 pathway is altered in about 80% of tumors.; (3) our … Continue reading

Posted in Ideas | Comments Off on Therapeutic insights into “awakening the sleeping/cancer-protecting angels” in mutant p53-expressing human tumors: Paeoniflorin, a natural compound isolated from Paeonia lactiflora pall and Paeonia veitchii Lynch, increases the expression of tumor suppressor p53 homologue TA-p73/p63, PTEN, TPM1, TIMP3, BTG2, PDCD4, SPRY1/2 and CCM1/KRIT1 and induces regression of p53-mutated human tumors via down regulation of its target gene, 28/December/2016, 6.30 pm

Natural product-derived Life-extension therapy: Celastrol, found in the root extracts of Tripterygium wilfordii and Celastrus regelii, inhibits the expression of Ribosomal protein S6 kinase 1 (p70S6 Kinase) and extends mammalian life span, 27/December/2016, 11. 45 pm

What they say? A recent study from the Institute of Healthy Ageing, Centre for Diabetes and Endocrinology, Department of Medicine, University College London, London WC1E 6JJ, UK shows that “Ribosomal protein S6 kinase 1 signaling regulates mammalian life span.” This study was published in … Continue reading

Posted in Ideas | Comments Off on Natural product-derived Life-extension therapy: Celastrol, found in the root extracts of Tripterygium wilfordii and Celastrus regelii, inhibits the expression of Ribosomal protein S6 kinase 1 (p70S6 Kinase) and extends mammalian life span, 27/December/2016, 11. 45 pm

Molecular therapy for N-Myc-overexpressing tumors: BMP4 increases the levels of tumor suppressor proteins, TAp63, TAp63 and Fbw7 (SCF Fbw7 ubiquitin ligase), inhibits the expression of pro-survival proteins N-Myc, Cyclin-E and Mcl-1, and stalls the progression of N-Myc-overexpressing cancers via down regulation of its target gene, 27/December/2015, 11.08 pm

Introduction: What they say A study from the Zhongnan Hospital of Wuhan University, Wuhan 430071, China; and Medical Research Institute, Wuhan University, Wuhan 430071, China shows that “Polo-like Kinase-1 Regulates Myc Stabilization and Activates a Feedforward Circuit Promoting Tumor Cell … Continue reading

Posted in Ideas | Comments Off on Molecular therapy for N-Myc-overexpressing tumors: BMP4 increases the levels of tumor suppressor proteins, TAp63, TAp63 and Fbw7 (SCF Fbw7 ubiquitin ligase), inhibits the expression of pro-survival proteins N-Myc, Cyclin-E and Mcl-1, and stalls the progression of N-Myc-overexpressing cancers via down regulation of its target gene, 27/December/2015, 11.08 pm

Natural product-derived regenerative therapy for improving muscle repair and strength in the elderly: AbM (Agaricus blazei Murill) decreases the expression of HOXA9, increases skeletal muscle regeneration and imporves muscle stem cells function and repair via up regulation of its target genes, 27/December/2016, 10.45 pm

Introduction: What they say A study from Faculty of Medicine, Friedrich-Schiller-University, Germany shows that “Epigenetic stress responses induce muscle stem-cell ageing by Hoxa9 developmental signals.” This research paper was published in the 30 November 2016 issue of the journal “Nature” … Continue reading

Posted in Ideas | Comments Off on Natural product-derived regenerative therapy for improving muscle repair and strength in the elderly: AbM (Agaricus blazei Murill) decreases the expression of HOXA9, increases skeletal muscle regeneration and imporves muscle stem cells function and repair via up regulation of its target genes, 27/December/2016, 10.45 pm

Therapeutic insights into “awakening the sleeping/cancer-protecting angels” in mutant p53-expressing human tumors: Valproic acid, used in the treatment of epilepsy, bipolar disorder and migraine headaches, increases the expression of tumor suppressor p53 homologue TA-p73/p63, PTEN, TPM1, TIMP3, BTG2, PDCD4, SPRY1/2 and CCM1/KRIT1 and induces regression of p53-mutated human tumors via down regulation of its target gene, 27/December/2016, 2.55 pm

From Significance of the study to Public health relevance: Given that: (1) Cancer suppressor p53 is mutated in more than 50% of human cancers of different tissue origin; (2) p53 pathway is altered in about 80% of tumors.; (3) our … Continue reading

Posted in Ideas | Comments Off on Therapeutic insights into “awakening the sleeping/cancer-protecting angels” in mutant p53-expressing human tumors: Valproic acid, used in the treatment of epilepsy, bipolar disorder and migraine headaches, increases the expression of tumor suppressor p53 homologue TA-p73/p63, PTEN, TPM1, TIMP3, BTG2, PDCD4, SPRY1/2 and CCM1/KRIT1 and induces regression of p53-mutated human tumors via down regulation of its target gene, 27/December/2016, 2.55 pm

Molecular therapy for Myocardial Infarction: Nifedipine, an antihypertensive drug, inhibits DNA damage responses, increases telomerase expression, inhibits telomere shortening, and promotes cardiomyocyte survival after myocardial infarction via up-regulation of PNUTS, 27/December/2016, 2.39 pm

What they say:  A recent study from the Institute for Cardiovascular Regeneration, Centre of Molecular Medicine, Frankfurt, Germany shows that “MicroRNA-34a regulates cardiac ageing and function.” This study was published in the 7 March  2013 issue of Nature  by Prof Dimmler, Boon, and others. What we say:  On the foundation of this interesting finding, Dr L Boominathan … Continue reading

Posted in Ideas | Comments Off on Molecular therapy for Myocardial Infarction: Nifedipine, an antihypertensive drug, inhibits DNA damage responses, increases telomerase expression, inhibits telomere shortening, and promotes cardiomyocyte survival after myocardial infarction via up-regulation of PNUTS, 27/December/2016, 2.39 pm

Cardiac rejuvenation therapy: Persimmon Tannin fruit extract suppresses tumor suppressor INK4a/p16 expression, and inhibits dilated cardiomyopathy and heart failure via up regulation of its target gene, 26/December/2016, 1.23 pm

Introduction: What they say A recent study from the Stem Cell Aging Group, Centro Nacional de Investigaciones Cardiovasculares, E-28029 Madrid, Spain shows that “Bmi1 limits dilated cardiomyopathy and heart failure by inhibiting cardiac senescence.” This study was published in the … Continue reading

Posted in Ideas | Comments Off on Cardiac rejuvenation therapy: Persimmon Tannin fruit extract suppresses tumor suppressor INK4a/p16 expression, and inhibits dilated cardiomyopathy and heart failure via up regulation of its target gene, 26/December/2016, 1.23 pm

Molecular therapy for Myocardial Infarction: PF-4708671, an inhibitor of p70 ribosomal S6 kinase 1, inhibits DNA damage responses, increases telomerase expression, inhibits telomere shortening, and promotes cardiomyocyte survival after myocardial infarction via up-regulation of PNUTS, 26/December/2016, 9.33 am

What they say:  A recent study from the Institute for Cardiovascular Regeneration, Centre of Molecular Medicine, Frankfurt, Germany shows that “MicroRNA-34a regulates cardiac ageing and function.” This study was published in the 7 March  2013 issue of Nature  by Prof Dimmler, Boon, and others. What we say:  On the foundation of this interesting finding, Dr L Boominathan … Continue reading

Posted in Ideas | Comments Off on Molecular therapy for Myocardial Infarction: PF-4708671, an inhibitor of p70 ribosomal S6 kinase 1, inhibits DNA damage responses, increases telomerase expression, inhibits telomere shortening, and promotes cardiomyocyte survival after myocardial infarction via up-regulation of PNUTS, 26/December/2016, 9.33 am