Introduction: What they say:
A recent study from the Institute of Biophysics, Chinese Academy of Sciences, Beijing, China shows that “Sox2 functions as a sequence-specific DNA sensor in neutrophils to initiate innate immunity against microbial infection.” This study was published in the 2 March 2015 issue of the Journal “Nature Immunology” [the number one journal in immunological research with an impact factor of 24.973] by Drs. Zusen Fan, Xia and others.
What we say:
On the foundation of this interesting finding, Dr L Boominathan PhD, Director-cum-chief Scientist of GBMD, reports that: Immune enhancement therapy: HIF-2α increases SOX2 expression and promotes innate immunity against bacterial infection via down-regulation of its target gene.
From Research Findings to Therapeutic Opportunity:
This study suggests, for the first time, HIF-2α, by decreasing the expression of its target gene, it may : (1) increase the expression of Sox2; (2) increase the ability of Sox2 to recognize bacterial DNA in cytoplasm; and (3) promote innate immunity against bacterial infection.
Together, pharmacological formulations encompassing “HIF-2α inducers” may be used to (1) enhance innate immunity against bacterial infection; and (2) promote bacterial resistance.
Details of the research findings:
Idea Proposed/Formulated by: Dr L Boominathan Ph.D.
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Undisclosed mechanistic information: How HIF-2α: (1) enhances innate immunity against bacterial infection; and (2) promotes bacterial resistance?
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Citation: Boominathan, L., Immune enhancement therapy: HIF-2α increases SOX2 expression and promotes innate immunity against bacterial infection via down-regulation of its target gene, 19/December/2016, 10.14 pm, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org
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