Introduction: What they say:
A study from the Department of Pharmacology, The University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA has reported that “miR-34a blocks osteoporosis and bone metastasis by inhibiting osteoclastogenesis and Tgif2.”
This study was published in the June 25, 2014 Nature [I.F >42] by Prof. Wan Y, Krzeszinski and others from the Department of Pharmacology, The University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA.
What we say:
On the foundation of this interesting finding, Dr L Boominathan, Director-cum-chief Scientist of GBMD, reports here that: MiR-143 inhibits the expression of Tgif2 and suppresses osteoporosis and bone metastasis via up-regulation of its target gene
From Research findings to Therapeutic utility:
MiR-143, by down-regulating its target gene, it may suppress the expression of Tgif2. Thereby, it may inhibit the progression of Osteoporosis and bone metastasis.
Thus, pharmacological formulations encompassing “MiR-143 activators or MiR-143 plus any of the known compounds that are in use to treat osteoporosis” can be used to inhibit osteoporosis and bone metastasis.
Details of the research findings:
Idea Formulated (with experimental evidence) by: Dr L Boominathan PhD
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Citation: Boominathan, L., Molecular therapy for Bone disorders: MiR-143 inhibits the expression of Tgif2 and suppresses osteoporosis and bone metastasis via up-regulation of its target gene, 18/December/2016, 10.33 pm., Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org
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