Molecular therapy for Bone disorders: MiR-143 inhibits the expression of Tgif2 and suppresses osteoporosis and bone metastasis via up-regulation of its target gene, 18/December/2016, 10.33 pm

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Introduction: What they say

A study from the Department of Pharmacology, The University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA has reported that “miR-34a blocks osteoporosis and bone metastasis by inhibiting osteoclastogenesis and Tgif2.”

This study was published in the June 25, 2014 Nature  [I.F >42] by Prof. Wan Y, Krzeszinski and others from  the Department of Pharmacology, The University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA.


What we say:

On the foundation of this interesting finding, Dr L Boominathan, Director-cum-chief Scientist of GBMD, reports here that: MiR-143 inhibits the expression of Tgif2 and suppresses osteoporosis and bone metastasis via up-regulation of its target gene


From Research findings to Therapeutic utility

MiR-143, by down-regulating its target gene, it may suppress the expression of Tgif2. Thereby, it may inhibit the progression of Osteoporosis and bone metastasis. 

price-50[easy_payment currency=”USD”]

Thus, pharmacological formulations encompassing “MiR-143 activators or MiR-143  plus any of the known compounds that are in use to treat osteoporosis” can be used to inhibit osteoporosis and bone metastasis.


Details of the research findings

Undisclosed mechanistic information: How MiR-143  suppresses the expression of Tgif2

Amount: $50#

Idea Formulated (with experimental evidence) by: Dr L Boominathan PhD

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 Reference:

CitationBoominathan, L., Molecular therapy for Bone disorders: MiR-143 inhibits the expression of Tgif2 and suppresses osteoporosis and bone metastasis via up-regulation of its target gene, 18/December/2016, 10.33 pm., Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org

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