Public health relevance:
Given that (1) more than 387 million people worldwide are affected by Diabetes mellitus (DM); (2) the life-long painful injection/drug treatment required to treat DM; and (3) the global economic cost spent for diabetes treatment in 2014 was little more than 600 billion US dollars, there is an urgent need to find: (i) a way to induce regeneration of adult β-cells that were lost in DM; (ii) a cheaper alternative to the existing expensive drugs; and (iii) a side-effect-free natural product-based drug.
From research findings to therapeutic opportunity:
This study suggests a small molecule Regenerative therapy for DM. PNUTS (a protein phosphatase), by decreasing the expression of its target gene, it may: (1) increase the expression of modulator of lipid homeostasis liver X receptor (LXR)-α; (2) decrease plasma levels of triglyceride and cholesterol; (3) protect against diet-induced weight-gain; and (4) increase insulin-secreting cell mass and function. [easy_payment currency=”USD”]
Thereby, it may increase insulin sensitivity and leanness. Thus, pharmacological formulations encompassing “PNUTS activators or PNUTS activators plus any of the known anti-metabolic compounds in use“ can be used to treat metabolic disorders, including DM.
Details of the research findings:
Idea Proposed/Formulated (with experimental evidence) by:
Dr L Boominathan Ph.D.
Terms & Conditions apply http://genomediscovery.org/registration/terms-and-conditions/
Undisclosed information: How PNUTS increases: (1) (LXR)-α expression; (2) and insulin-secreting cell mass and function.
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Citation: Boominathan, L., Molecular therapy for Metabolic disorders: PNUTS (a protein phosphatase) increases (LXR)-α expression, insulin-secreting cell mass and function via down regulation of its target genes, 2/December/2016, 7.01 am, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org
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