Natural product-derived anti-ageing therapy: Shikonin, the major component of Zicao (also known as purple gromwell, the dried root of Lithospermum erythrorhizon), activates autophagy and extend lifespan via up regulation of its target gene, 2/December/2016, 7.14 pm

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What we say:

Dr L Boominathan PhD, Director-cum-chief Scientist of GBMD, reports here that: Shikonin, the major component of Zicao (also known as purple gromwell, the dried root of Lithospermum erythrorhizon),  activates autophagy and extend lifespan via up regulation of its target gene

[easy_payment currency=”USD”]price-100


From Significance of the study to Therapeutic opportunity:

This study suggests, for the first time, that Shikonin, by increasing the expression of its target gene, it may: (1) enhance autophagy, (2) promote leanness; (3) increase insulin sensitivity; (4) improve motor function; (5) increase resistance to oxidative stress; (6) alleviate ageing features; and (7) promote longevity( fig.1 &2).

purple-gromwell

Figure 1. Shikonin, found in Zicao (also known as purple gromwell), enhances autophagy, increases insulin sensitivity and promotes longevity via up regulation of its target gene

Shikonin

Thus, pharmacological formulations encompassing “Shikonin or its analogues or Shikonin plus any of the known anti-ageing compoundsmay be used to increase the life span of an individual.


Details of the research findings

Idea Proposed/Formulated byDr L Boominathan PhD

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Amount: $ 100

Undisclosed mechanistic information: How Shikonin does activate autophagy and extend lifespan?

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References:

Web: http://genomediscovery.org or newbioideas.com

CitationBoominathan, L., Natural product-derived anti-ageing therapy: Shikonin, the major component of Zicao (also known as purple gromwell, the dried root of Lithospermum erythrorhizon),  activates autophagy and extend lifespan via up regulation of its target gene, 2/December/2016, 7.10 pm

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