Natural product-derived antiviral therapy against chikungunya (CHIKV) and Zika (ZIKV) viruses: Kukoamine A (KuA), a spermine alkaloid derived from Cortex lycii radicis and Lycium chinense among others, decreases spermidine/spermine N1-acetyltransferase (SAT) expression, depletes spermidine and Spermine levels, and restricts Chikungunya and Zika viruses replication via up regulation of its target gene, 3/December/2015, 5.38 pm

Natural product-derived therapy for Myocardial Infarction: Guggulsterone (4,17(20)-pregnadiene-3,16-dione), a resin found in the Guggul herb Commiphora mukul, inhibits DNA damage responses, and telomere shortening, and promotes cardiomyocyte survival after myocardial infarction via up-regulation of PNUTS, 3/December/2016, 6.55 am
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Natural product Life-extension therapy: EHHM (E‑[6′-(5′-hydroxypentyl)tricosyl]-4-hydroxy-3-methoxycinnamate), found in Livistona Chinensis, inhibits the expression of Ribosomal protein S6 kinase 1 (p70S6 Kinase) and extends mammalian life span, 3/December/2016, 5.57 pm
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Introduction: What they say

A study from the Viral Populations and Pathogenesis Unit, Institut Pasteur, CNRS UMR 3569, 25–28 rue du Dr. Roux, 75724 Paris Cedex 15, France shows that “Interferon-Induced Spermidine-Spermine Acetyltransferase and Polyamine Depletion Restrict Zika and Chikungunya Viruses.”  This research paper was published in the 10 August 2016 issue of the journal “Cell Host and microbe” [One of the best research journals  in Infectious biology with an I.F of 12.552] by Prof. Marco Vignuzzi, Bryan C. Mounce and others.


What we say

On the foundation of this interesting finding, Dr L Boominathan PhD, Director-cum-chief Scientist of GBMD, reports, for the first time, a Natural product-derived antiviral therapy against chikungunya (CHIKV) and Zika (ZIKV) viruses. Kukoamine A (KuA), a spermine alkaloid derived from Cortex lycii radicis and Lycium chinense among others, decreases spermidine/spermine N1-acetyltransferase (SAT) expression, depletes spermidine and Spermine levels, and restricts Chikungunya and Zika viruses replication via up regulation of its target gene


What is known?

Prof. Marco Vignuzzi’s research team has recently shown that induction of type I interferon results in: a) upregulation of SAT1; b) depletion of spermidine and spermine levels; and c) inhibition of Chikungunya and Zika viruses production. They have further validated this by showing that exogenous administration of Polyamines (spermidine and spermine) restores virus replication.


From Research findings to Therapeutic opportunity:

This study suggests, for the first time, a natural product-based antiviral therapy against RNA viruses such as chikungunya virus (CHIKV) and Zika virus (ZIKV).

price-300[easy_payment currency=”USD”]

Kukoamine A (KuA), by increasing the expression of its target gene, it may increase the expression of spermidine/spermine N1-acetyltransferase (SAT1) (Figures 1 -3). Thereby, it may: (1) decrease polyamine spermidine and spermine levels; (2) stall CHIKV and ZIKV replication; (3) promote clearance of Zika and Chikungunya Viruses; and (4) strengthen antiviral immunity against RNA viruses.

cortex-lycii-radicis

Figure 1 Kukoamine A (KuA), derived from Cortex lycii radicis and Lycium chinense, as indicated below, inhibits the replication of Chikungunya and Zika viruses

Lycium chinense

Figure 2. Kukoamine A (KuA) is  also found in Lycium chinense

Image result for Kukoamine A

Figure 3. Kukoamine A

Thus, pharmacological formulations encompassing ” Kukoamine A (KuA) or its analogues or Kukoamine A plus any of the known antiviral compounds” may be used to treat infections caused by chikungunya (CHIKV) and Zika (ZIKV) viruses.


Details of the research findings:

Idea Proposed/Formulated (with experimental evidence) by: Dr L Boominathan Ph.D.

Terms & Conditions apply http://genomediscovery.org/registration/terms-and-conditions/

Undisclosed information: How does Kukoamine A (KuA) increase the expression of spermidine/spermine N1-acetyltransferase (SAT1)?

Amount: $300

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References:

Web: http://genomediscovery.org or http://newbioideas.com

Citation: Boominathan, L., Natural product-derived antiviral therapy against chikungunya (CHIKV) and Zika (ZIKV) viruses: Kukoamine A (KuA), a spermine alkaloid derived from Cortex lycii radicis and Lycium chinense among others, decreases spermidine/spermine N1-acetyltransferase (SAT) expression, depletes spermidine and Spermine levels, and restricts Chikungunya and Zika viruses replication via up regulation of its target gene, 3/December/2015, 5.38 pm, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org

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