Natural product-derived Lifespan extension therapy: Persimmon tannin fruit extract increases life span via up-regulation of its target gene BubR1, 10/December/2016, 7.41 pm

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 What they say: Introduction

A recent study from the Department of Genetics, Paul F. Glenn Laboratories for the Biological Mechanisms of Aging Harvard Medical School, Boston,USA; and Department of Pharmacology, School of Medicine, The University of New South Wales, Australia shows that Sirtuin-2 induces the checkpoint kinase BubR1 to increase lifespan. This study was published in the 1 July  2014 issue of the journal  “EMBO” by Prof Sinclair, North BJ, and others.


What we say

On the foundation of this interesting finding, Dr L Boominathan PhD, Director-cum-chief Scientist of GBMD, reports that:  Natural product-derived Lifespan extension therapy: Persimmon tannin fruit extract increases life span via up-regulation of its target gene BubR1


What is known? 

I have recently published that  Persimmon tannin fruit extract(1) increases the expression of ERBB2/Her2 and promotes  dedifferentiation of cardiomyocytes; and (2) increases NMN levels, decreases age-associated weight gain, augments energy metabolism, improves physical activity and insulin sensitivity, promotes healthy lipid profile, and  improves eye function


From Research Findings to Therapeutic Opportunity

This study suggests a natural product-based life extension therapy. Persimmon tannin fruit extractby decreasing the expression of its target gene, it may increase the expression of BuBR1.

price-100[easy_payment currency=”USD”]

Thereby, it may: (1) delay diseases of aging; (2) slow down aging; and (3) prolong median life span. Thus, pharmacological formulations encompassing “Persimmon tannin extract or an active compound isolated from it” may be used to extend the lifespan of an individual. 

persimmon

Figure 1.Persimmon Tannin may promote  mammalian life span via up regulation of BuBR1

Persimmon tannin

Figure 2. Persimmon tannin fruits may function as longevity promoters

Details on the research findings

Idea Proposed/Formulated (with experimental evidence) by:

Dr L Boominathan Ph.D.

Amount: $100#

Undisclosed mechanistic information: How Persimmon tannin fruit extract  increases the expression of BubR1 and extends mammalian life-span

Terms & Conditions apply http://genomediscovery.org/registration/terms-and-conditions/

# Research cooperation


References

Web: http://genomediscovery.org or http://newbioideas.com

CitationBoominathan, L., Natural product-derived Lifespan extension therapy: Persimmon tannin fruit extract increases life span via up-regulation of its target gene BubR1, 10/December/2016, 7.41 pm,  Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org

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