Natural product-derived PD-L1 pathway blockade enhances the efficacy of Cancer immunotherapy: γ-Bisabolene, one of the components in Cardamom, Cubeb, lemon, and Oregano among others, inhibits the expression of PD-L1, inhibits inflammatory signalling and the number of tumor-infiltrating lymphocytes and macrophages, increases Cytotoxic activity of T-cells, decreases tumor burden and increases survival via up-regulation of its target gene, 24/December/2016, 10.45 pm

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Introduction:What they say:

A recent study from Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Unit 108, 1515 Holcombe Boulevard, Houston, TX 77030, USA shows that “Deubiquitination and Stabilization of PD-L1 by CSN5.” This study was published in the 12 December 2016 issue of Cancer cell (one of the best journals in Cancer Science with an impact factor of 23.523) by Prof Mien-Chie Hung, Lim SO and others.


What we say

On the foundation of this interesting finding, Dr L Boominathan PhD, Director-cum-chief Scientist of GBMD, reports that: Natural product-derived PD-L1 pathway blockade enhances the efficacy of Cancer immunotherapy: γ-Bisabolene, one of the components in Cardamom, Cubeb, lemon, and Oregano among others, inhibits the expression of PD-L1, inhibits inflammatory signalling and the number of tumor-infiltrating lymphocytes and macrophages, increases Cytotoxic activity of T-cells, decreases tumor burden and increases survival via up-regulation of its target gene


What is known?

It has recently been shown that blocking cell surface receptor PD-1 with antibodies one could make tumors shrink. This work, relating to Cancer immunotherapy, has been chosen as Science’s breakthrough of the year recently.


From Research Findings to Therapeutic opportunity

γ-Bisabolene, by increasing the expression of its target gene, it may  ubiquitinate and destabilize PD-L1 (fig. 1). Thereby, it may: (i) diminish PD-L1 expression in cancer cells; (ii) inhibit inflammatory TNFα signaling; (iii) decrease the number of tumor-infiltrating lymphocytes and macrophages; (iv) increase T-cell anti-tumor immunity; (v) decrease tumor burden; and (vi) increase survival of patients with breast cancer (figs 1-5).  

gbisabolene-inhibits-pdl1-expression

Figure 1. Mechanistic insight into how γ-Bisabolene enhances the efficacy of cancer immunotherapy. γ-Bisabolene, by down regulating the expression of PD-L1 in cancer cells, it augments T-cell mediated anti-tumor immunity

Figure 1 γ-Bisabolene Thymoquinone, isolated from Monarda Fistulosa, protects  against Sepsis via up-regulation of Sestrin-2 and induction of mitophagy

Fig 2 γ-Bisabolene, found in Cardamom, among others, as indicated below, augments T-cell mediated anti-tumor immunity

bisbolene-found-in-Cubeb-pepper-leaves

Fig 3. Cubeb-pepper-leaves contain  γ-Bisabolene

Oregano contain

Fig 4. Oregano contains γ-Bisabolene

γ-Bisabolene

Fig 5. γ-Bisabolene

Thus, pharmacological formulations encompassing “γ-Bisabolene or its analogues or γ-Bisabolene plus any of the known anticancer agents may be used to (i) inhibit the progression of tumors; and (ii) enhance the efficacy of Cancer immunotherapy.price-300[easy_payment currency=”USD”]


Details of the research findings:

Idea Proposed/Formulated (with experimental evidence) by: Dr L Boominathan Ph.D.

Terms & Conditions apply http://genomediscovery.org/registration/terms-and-conditions/

Amount: $300

Undisclosed mechanistic information: How γ-Bisabolene suppresses the expression of PD-L1 and augments anti-tumor immunity

For purchase and payment details, you may reach us at admin@genomediscovery.org

# Research cooperation


References

Citation: Boominathan, L., Natural product-derived PD-L1 pathway blockade enhances the efficacy of Cancer immunotherapy: γ-Bisabolene, one of the components in Cardamom, Cubeb, lemon, and Oregano among others, inhibits the expression of PD-L1, inhibits inflammatory signalling and the number of tumor-infiltrating lymphocytes and macrophages, increases Cytotoxic activity of T-cells, decreases tumor burden and increases survival via up-regulation of its target gene, 24/December/2016, 10.45 pm, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org

Web: http://genomediscovery.org or http://newbioideas.com

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