Natural product-derived regenerative therapy for improving muscle repair and strength in the elderly: α-Lipoic acid, found in Brussels, broccoli, rice bran and among others, decreases the expression of HOXA9, increases skeletal muscle regeneration and imporves muscle stem cells function and repair via up regulation of its target genes, 24/December/2016, 11.14 pm

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Introduction: What they say

A study from Faculty of Medicine, Friedrich-Schiller-University, Germany shows that “Epigenetic stress responses induce muscle stem-cell ageing by Hoxa9 developmental signals.” This research paper was published in the 30 November 2016 issue of the journal “Nature” [One of the best research journals in General Science with an I.F of 38+] by Prof.Lenhard Rudolph, Stefan Tümpel, Simon Schwörer and others.


What we say:

On the foundation of this interesting finding, Dr L Boominathan PhD, Director-cum-chief Scientist of GBMD, reports that: Natural product-derived regenerative therapy for improving muscle repair and strength in the elderly: α-Lipoic acid, found in Brussels, broccoli, rice bran and among others, decreases the expression of HOXA9, increases skeletal muscle regeneration and imporves muscle stem cells function and repair via up regulation of its target genes


What is known?

Prof. Lenhard Rudolph’s research team has recently shown that deletion of HOXA9 in mice results in a) down regulation of inhibitors of muscle stem cells function, including Wnt, TGFß, JAK/STAT and senescence signalling; and b) improved muscle stem cells regeneration and function. Conversely, overexpression of HOXA9 has been shown to promote ageing-associated features in muscle stems cells.


From Research findings to Therapeutic opportunity:

This study suggests, for the first time, a natural product-based regenerative therapy for improving muscle strength and repair in the elderly. αLipoic acid, by increasing the expression of its target gene, it may decrease the levels of HOXA9 (fig.1).

lipoic-acid-promotes-muscle-stem-cell-regeneration-via-down-regulation-of-hoxa9

Figure 1. Mechanistic insight into how Lipoic acid promotes muscle stem cell regeneration. Lipoic acid, found in Brussels, broccoli, and among others, promotes muscle stem cell repair and regeneration via down regulation of HOXA9

Thereby, it may: (1) down regulate inhibitors of muscle stem cells function; and (2) improve of muscle stem cells regeneration and function. Thus, pharmacological formulations encompassing “α-Lipoic acid or its analogues or αLipoic acid plus any of the known compounds that promote muscle regeneration” may be used to suppress muscle stem-cell ageing, age-associated physiological decline and improve health span.price-quote[easy_payment currency=”USD”]

 Figure 1   α-Lipoic acid, found in brussels etc., inhibits the progression of NDHi-aggravated middle ear infection via up-regulation of MKP1/DUSP-1 and down-regulation of CXCL5

Figure 2 α-Lipoic acid, found in Brussels, broccoli, rice bran, and  among others, promotes muscle stem cell repair and regeneration

alpha-lipoic-acid

Figure 3. α-Lipoic acid


Details of the research findings:

Idea Proposed/Formulated (with experimental evidence) by: Dr L Boominathan Ph.D.

Terms & Conditions apply http://genomediscovery.org/registration/terms-and-conditions/

Undisclosed mechanistic information: How αLipoic acid decreases the expression of HOXA9

Amount: $500

For purchase and payment details, you may reach us at info@genomediscovery.org

# Research cooperation


References:

Web: http://genomediscovery.org or http://newbioideas.com

Citation: Boominathan, L., Natural product-derived regenerative therapy for improving muscle repair and strength in the elderly: α-Lipoic acid, found in Brussels, broccoli, rice bran and among others, decreases the expression of HOXA9, increases skeletal muscle regeneration and imporves muscle stem cells function and repair via up regulation of its target genes, 24/December/2016, 11.14 pm, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org

Courtesy: When you cite us, you drop us a line at info@genomediscovery.org

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