Natural product-derived therapy for Bone disorders: Matrine, found in herb Sophora flavescens, inhibits the expression of Tgif2 and suppresses osteoporosis and bone metastasis via up-regulation of its target gene, 21/December/2016, 6.20 pm

Molecular therapy for Myocardial Infarction: PDLIM1/2 (PDZ And LIM Domain 1) inhibit DNA damage responses, increase telomerase expression, inhibit telomere shortening, and promote cardiomyocyte survival after myocardial infarction via up-regulation of PNUTS, 21/December/2016, 2.46 pm
December 21, 2016
Immune enhancement therapy: Lithium increases SOX2 expression and promotes innate immunity against bacterial infection via down-regulation of its target gene, 21/December/2016, 10.43 pm
December 21, 2016
Show all

Introduction: What they say

A study from the Department of Pharmacology, The University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA has reported that “miR-34a blocks osteoporosis and bone metastasis by inhibiting osteoclastogenesis and Tgif2.”

This study was published in the June 25, 2014 Nature  [I.F >42] by Prof. Wan Y, Krzeszinski and others from  the Department of Pharmacology, The University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA.


What we say:

On the foundation of this interesting finding, Dr L Boominathan, Director-cum-chief Scientist of GBMD, reports here that: Matrine, found in herb Sophora flavescens,  inhibits the expression of Tgif2 and suppresses osteoporosis and bone metastasis via up-regulation of its target gene


From Research findings to Therapeutic utility

Matrine, by down-regulating its target gene, it may suppress the expression of Tgif2. Thereby, it may inhibit the progression of Osteoporosis and bone metastasis. 

Figure 1.

Figure 1. Sophora flavescens. Matrine, isolated from Sophora flavescens, inhibits Osteoporosis and bone metastasis via down regulation of Tgif2

price-50[easy_payment currency=”USD”]

matrine_structure

Figure 2. Matrine

Thus, pharmacological formulations encompassing “Matrine or Matrine  plus any of the known compounds that are in use to treat osteoporosis” can be used to inhibit osteoporosis and bone metastasis.


Details of the research findings

Undisclosed mechanistic information: How Matrine  suppresses the expression of Tgif2

Amount: $50#

Idea Formulated (with experimental evidence) by: Dr L Boominathan PhD

Terms & Conditions apply http://genomediscovery.org/registration/terms-and-conditions/

#Research cooperation

For purchase & payment details, you may reach us at admin@genomediscovery.org


 References:

CitationBoominathan, L., Natural product-derived therapy for Bone disorders: Matrine, found in herb Sophora flavescens, inhibits the expression of Tgif2 and suppresses osteoporosis and bone metastasis via up-regulation of its target gene, 21/December/2016, 6.20 pm., Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org

Courtesy: When you cite drop us a line at info@genomediscovery.org

Web: http://genomediscovery.org or http://newbioideas.com

Comments are closed.