Natural product-derived therapy for Human Leukemias: γ-Bisabolene, one of the components in Cardamom, Cubeb, lemon, and Oregano among others, suppresses B-Cell and myeloid leukemias via up regulation of the tumor suppressor IRF4, 11/December/2016, 11.07 pm

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Introduction: What they say

Noble laureate in Physiology/Medicine (1975) Prof. David Baltimore, from California Institute of Technology, California, USA, had reported in the July 8, 2014 issue of the Journal “Blood” that: “Dual mechanisms by which MiR-125b represses IRF4 to induce myeloid/B-cell leukemias.” 


What we say:

On the foundation of this interesting finding, Dr L Boominathan PhD, Director-cum-chief Scientist of GBMD, reports that: Natural product-derived therapy for Human Leukemias: γ-Bisabolene, one of the components in Cardamom, Cubeb, lemon, and Oregano among others, suppresses B-Cell and myeloid leukemias via up regulation of the tumor suppressor IRF4. 


From Research findings to Therapeutic opportunity:

This study suggests that γ-Bisabolene, by increasing the expression of  its target gene, it may increase the expression of a number of tumor suppressor genes, including IRF4. Thereby, it could inhibit the progression of B-Cell and myeloid leukemias (figs. 1 and 2).

Figure 1 γ-Bisabolene Thymoquinone, isolated from Monarda Fistulosa, protects  against Sepsis via up-regulation of Sestrin-2 and induction of mitophagy

Fig 1 γ-Bisabolene, found in Cardamom, among others, as indicated below, increases the expression IRF4 and inhibits the progression of B-Cell and myeloid leukemias via up regulation of its target gene

bisbolene-found-in-Cubeb-pepper-leaves

Fig2. Cubeb-pepper-leaves contain  γ-Bisabolene

 

Oregano contain

Fig3. Oregano contains γ-Bisabolene

γ-Bisabolene

Fig4. γ-Bisabolene

Mechanistic insights into how bisabolene-induces-irf4-expression

Figure 5. Mechanistic insights into how γ-Bisabolene increases the expression IRF4 and inhibits the progression of B-Cell and myeloid leukemias

Taken together, this study suggests that pharmacological formulations encompassing       “γ-Bisabolene or its analogues or γ-Bisabolene in combination with other anticancer drugs may be used to inhibit B-Cell and myeloid leukemias (fig 4).


Details of the research details

Idea Proposed/Formulated byDr L Boominathan Ph.D.

Terms & Conditions apply http://genomediscovery.org/registration/terms-and-conditions/

Undisclosed mechanistic information: How γ-Bisabolene increases the expression of IRF4?

Amount: $ 50

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# Research cooperation


References:

Web: http://genomediscovery.org or newbioideas.com

CitationBoominathan, L., Natural product-derived therapy for Human Leukemias: γ-Bisabolene, one of the components in Cardamom, Cubeb, lemon, and Oregano among others, suppresses B-Cell and myeloid leukemias via up regulation of the tumor suppressor IRF4, 11/December/2016, 11.07 pm,  Genome-2-Bio-Medicine Discovery Center.

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