Natural product-derived therapy for Human Leukemias: Cucurbitacin E, found abundantly in Watermelons, suppresses B-Cell and myeloid leukemias via up regulation of the tumor suppressor IRF4, 14/December/2016, 10.19 pm

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Introduction: What they say

Noble laureate in Physiology/Medicine (1975) Prof. David Baltimore, from California Institute of Technology, California, USA, had reported in the July 8, 2014 issue of the Journal “Blood” that: “Dual mechanisms by which MiR-125b represses IRF4 to induce myeloid/B-cell leukemias.” 


What we say:

On the foundation of this interesting finding, Dr L Boominathan PhD, Director-cum-chief Scientist of GBMD, reports that: Natural product-derived therapy for Human Leukemias: Cucurbitacin E, found abundantly in Watermelons, suppresses B-Cell and myeloid leukemias via up regulation of the tumor suppressor IRF4


From Research findings to Therapeutic opportunity:

This study suggests that Cucurbitacin E, by increasing the expression of  its target gene, it may increase the expression of a number of tumor suppressor genes, including IRF4. Thereby, it could inhibit the progression of B-Cell and myeloid leukemias (fig. 1).

cucurbitacin-e-increases-irf4-expression

Figure 1. Mechanistic insight into how Cucurbitacin E increases the expression of IRF4

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Taken together, this study suggests that pharmacological formulations encompassing       Cucurbitacin E or its analogues or Cucurbitacin E in combination with other anticancer drugs may be used to inhibit B-Cell and myeloid leukemias.


Details of the research details

Idea Proposed/Formulated byDr L Boominathan Ph.D.

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Undisclosed mechanistic information: How Cucurbitacin E increases the expression of IRF4?

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References:

Web: http://genomediscovery.org or newbioideas.com

CitationBoominathan, L.,  Natural product-derived therapy for Human Leukemias: Cucurbitacin E, found abundantly in Watermelons, suppresses B-Cell and myeloid leukemias via up regulation of the tumor suppressor IRF4, 14/December/2016, 10.19 pm,  Genome-2-Bio-Medicine Discovery Center.

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