Natural product-derived therapy for Human Leukemias: Eriocitrin, found in lemons, suppresses B-Cell and myeloid leukemias via up regulation of the tumor suppressor IRF4, 10/December/2016, 11.56 pm

Natural product-derived therapy for Human Leukemias: Ganoderma lucidum suppresses B-Cell and myeloid leukemias via up regulation of the tumor suppressor IRF4, 10/December/2014, 11.48 pm
December 10, 2016
Natural product-derived Lifespan extension therapy: Saponin, found in Panax Japonicus and Soapworts among others, increases life span via up-regulation of its target gene BubR1, 11/December/2016, 7.07 pm
December 11, 2016
Show all

Introduction: What they say:

Noble laureate in Physiology/Medicine (1975) Prof. David Baltimore, from California Institute of Technology, California, USA, had reported in the July 8, 2014 issue of the Journal “Blood” that: “Dual mechanisms by which MiR-125b represses IRF4 to induce myeloid/B-cell leukemias.” 


What we say:

On the foundation of this interesting finding, Dr L Boominathan PhD, Director-cum-chief Scientist of GBMD, reports that:  Natural product-derived therapy for Human Leukemias: Eriocitrin, found in lemons, suppresses B-Cell and myeloid leukemias via up regulation of the tumor suppressor IRF4. 


From Research findings to Therapeutic opportunity:

This study suggests that Eriocitrin, by increasing the expression of  its target gene, it may increase the expression of a number of tumor suppressor genes, including IRF4. Thereby, it could inhibit the progression of B-Cell and myeloid leukemias (figs. 1 and 2).

Lemon tree

Figure 1. Lemon tree

Figure 1. Pueraria-lobata. Eriocitrin, found in lemons, inhibits human cancer cell proliferation via down-regulation of Tripeptidyl Peptidase 1 (TPP1) and telomerase

Figure 2. Lemon fruits. Eriocitrin, isolated from  lemons, increases the expression IRF4 and inhibits the progression of B-Cell and myeloid leukemias via up regulation of its target gene

Image result for Eriocitrin

Figure 3. Eriocitrin

Taken together, this study suggests that pharmacological formulations encompassing       ” Eriocitrin or its analogues or  Eriocitrin in combination with other anti-cancer drugs may be used to inhibit B-Cell and myeloid leukemias (fig 3).


Details of the research details

Idea Proposed/Formulated byDr L Boominathan Ph.D.

Terms & Conditions apply http://genomediscovery.org/registration/terms-and-conditions/

Undisclosed mechanistic information: How Eriocitrin increases the expression of IRF4?

Amount: $ 50

For purchase and payment details, you may reach us at admin@genomediscovery.org

# Research cooperation


References:

Web: http://genomediscovery.org or newbioideas.com

CitationBoominathan, L., Natural product-derived therapy for Human Leukemias: Eriocitrin, found in lemons, suppresses B-Cell and myeloid leukemias via up regulation of the tumor suppressor IRF4, 10/December/2016, 11.56 pm,  Genome-2-Bio-Medicine Discovery Center.

Courtesy: When you cite drop us a line at info@genomediscovery.org

 

Comments are closed.