Natural product-derived therapy for Human Leukemias: Kukoamine A (KuA), a spermine alkaloid derived from Cortex lycii radicis and Lycium chinense among others, suppresses B-Cell and myeloid leukemias via up regulation of the tumor suppressor IRF4, 15/December/2016, 10.53 pm

Anti-telomerase cancer therapy: MiR-30b suppresses the expression of Tripeptidyl Peptidase 1 (TPP1) and inhibits cancer progression via down-regulation of it target gene, 15/December/2016, 10.37 pm
December 15, 2016
Life-extension therapy: MiRNA-1827 inhibits the expression of Ribosomal protein S6 kinase 1 (p70S6 Kinase) and extends mammalian life span, 15/December/2016, 10.57 pm
December 15, 2016
Show all

Introduction: What they say

Noble laureate in Physiology/Medicine (1975) Prof. David Baltimore, from California Institute of Technology, California, USA, had reported in the July 8, 2014 issue of the Journal “Blood” that: “Dual mechanisms by which MiR-125b represses IRF4 to induce myeloid/B-cell leukemias.” 


What we say:

On the foundation of this interesting finding, Dr L Boominathan PhD, Director-cum-chief Scientist of GBMD, reports that: Natural product-derived therapy for Human Leukemias: Kukoamine A (KuA), a spermine alkaloid derived from Cortex lycii radicis and Lycium chinense among others, suppresses B-Cell and myeloid leukemias via up regulation of the tumor suppressor IRF4


From Research findings to Therapeutic opportunity:

This study suggests that Kukoamine A (KuA), by increasing the expression of  its target gene, it may increase the expression of a number of tumor suppressor genes, including IRF4. Thereby, it could inhibit the progression of B-Cell and myeloid leukemias (fig. 1).

kukoamine-increases-irf4-expression

Figure 1. Mechanistic insight into how Kukoamine increases the expression of IRF4

price-100[easy_payment currency=”USD”]

Taken together, this study suggests that pharmacological formulations encompassing       Kukoamine A (KuA) or its analogues or Kukoamine A (KuA) in combination with other anticancer drugs may be used to inhibit B-Cell and myeloid leukemias.


Details of the research details

Idea Proposed/Formulated byDr L Boominathan Ph.D.

Terms & Conditions apply http://genomediscovery.org/registration/terms-and-conditions/

Undisclosed mechanistic information: How Kukoamine A increases the expression of IRF4?

Amount: $ 100

For purchase and payment details, you may reach us at admin@genomediscovery.org

# Research cooperation


References:

Web: http://genomediscovery.org or newbioideas.com

CitationBoominathan, L.,  Natural product-derived therapy for Human Leukemias: Kukoamine A (KuA), a spermine alkaloid derived from Cortex lycii radicis and Lycium chinense among others, suppresses B-Cell and myeloid leukemias via up regulation of the tumor suppressor IRF4, 15/December/2016, 10.53 pm,  Genome-2-Bio-Medicine Discovery Center.

Courtesy: When you cite drop us a line at admin@genomediscovery.org

Comments are closed.