Natural product-derived therapy for Human Leukemias: Naringenin, found in grapefruit, suppresses B-Cell and myeloid leukemias via up regulation of the tumor suppressor IRF4, 12/December/2016, 9.34 pm

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Introduction: What they say

Noble laureate in Physiology/Medicine (1975) Prof. David Baltimore, from California Institute of Technology, California, USA, had reported in the July 8, 2014 issue of the Journal “Blood” that: “Dual mechanisms by which MiR-125b represses IRF4 to induce myeloid/B-cell leukemias.” 


What we say:

On the foundation of this interesting finding, Dr L Boominathan PhD, Director-cum-chief Scientist of GBMD, reports that: Natural product-derived therapy for Human Leukemias:Naringenin, found in grapefruit, suppresses B-Cell and myeloid leukemias via up regulation of the tumor suppressor IRF4


From Research findings to Therapeutic opportunity:

This study suggests that Naringenin, by increasing the expression of  its target gene, it may increase the expression of a number of tumor suppressor genes, including IRF4. Thereby, it could inhibit the progression of B-Cell and myeloid leukemias (figs. 1 and 2).

Image result for Naringenin

Figure 1. Naringenin

Figure 1  Narigenin, found in grape fruit, extract inhibits pulmonary tuberculosis via down-regulation of (Toll-like receptor-TLR) TLR-2 and Chemokine CXCL5 and up-regulation of phosphatase MKP-1

Figure 2 Naringenin, found in grapefruit, increases the expression IRF4 and inhibits the progression of B-Cell and myeloid leukemias via up regulation of its target gene

Figure 3. Mechanistic insight into how Naringenin increases the expression of IRF4

Taken together, this study suggests that pharmacological formulations encompassing       “Naringenin or its analogues or Naringenin in combination with other anticancer drugs may be used to inhibit B-Cell and myeloid leukemias (fig 4).


Details of the research details

Idea Proposed/Formulated byDr L Boominathan Ph.D.

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Undisclosed mechanistic information: How Naringenin increases the expression of IRF4?

Amount: $ 50

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References:

Web: http://genomediscovery.org or newbioideas.com

CitationBoominathan, L., Natural product-derived therapy for Human Leukemias: Naringenin, found in grapefruit, suppresses B-Cell and myeloid leukemias via up regulation of the tumor suppressor IRF4, 12/December/2016, 9.35 pm,  Genome-2-Bio-Medicine Discovery Center.

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